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ANTICHOLINESTHERASE ACTIVITY AND LIPID PEROXIDATION AS CRITERIA OF SAFETY IN DERMAL DIAZINON EXPOSURE

ANTICHOLINESTHERASE ACTIVITY AND LIPID PEROXIDATION AS CRITERIA OF SAFETY IN DERMAL DIAZINON EXPOSURE

https://doi.org/10.33573/ujoh2008.03.035

Yastrub T.A., Leonenko N.C., Kirsenko V.V., Kovalenko V.F.

ANTICHOLINESTHERASE ACTIVITY AND LIPID PEROXIDATION AS CRITERIA OF SAFETY IN DERMAL DIAZINON EXPOSURE

State Institution «Institute for Occupational Health» of the Academy of Medical Sciences of Ukraine

Full article (PDF), UKR


Comparative evaluation of the developed calculation method for determination of the threshold permissible level (TPL) for skin contaminated by Diazinon and an experiment with this pesticide application to the rat skin were performed. The levels of cholinesterase activity in blood plasma, erythrocytes and brain and indices of prooxidant-antioxidant equilibrium were consid¬ered as criteria of safe exposure. It is shown that the value of TPL for Diazinon fully coincides with the no-observed-effect-level established in the experiment. It is supported by determination of cholinesterase level in blood plasma, erythrocytes and brain. The state of the prooxidant-antioxidant equilibrium (thiobarbital-acid-active-products and the content of ceruloplasmin), showing the tendency to the change in lipid peroxidation, points to the effect of this organophosphate insecticide on the body.

Key words: diazinon, threshold permissible level (TPL) of skin contamination, anticholinestherase activity, lipid peroxidation

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