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EFFECT OF GLUTARGIN ON THE POOL OF FREE AMINOACIDS IN THE RAT BLOOD, POISONED BY DIFFERENT LEAD DISPERSED FORMS

EFFECT OF GLUTARGIN ON THE POOL OF FREE AMINOACIDS IN THE RAT BLOOD, POISONED BY DIFFERENT LEAD DISPERSED FORMS

2(30) 2012

DOI xxxxxxxx

Lazarenko I. A., Derkach E. A., Melnikova N. M.

EFFECT OF GLUTARGIN ON THE POOL OF FREE AMINOACIDS IN THE RAT BLOOD, POISONED BY DIFFERENT LEAD DISPERSED FORMS

National University of Life and Environmental Sciences of Ukraine, Kyiv

Full article (PDF), UKR

The purpose was to investigate the influence of the preparation Glutargin on the content of free amino acids in the blood of rats with lead intoxication, simulated by oral administration of lead acetate at the dose of 70 mg / kg body animal weight (macrodispersed form) and lead nanoparticles (nanoforms) in the similar dose. Glutargin was administered to rats orally from the first day of the exposure in the dose of 100 mg / kg body weight. Intact animals received 0,9 % NaCl orally. It was found that the introduction of Glutargin with lead intoxication reduced the toxic effect of lead on the pool of amino acids, which contributed to normalization of protein synthesis in the affected organs and tissues.

Key words: macrodispersed form of lead, lead nanoform, Glutargin, free amino acids, blood

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