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METHODS OF DETERMINATION OF THE DEGREE OF CYTOTOXICITY OF INDUSTRIAL DUSTS "IN VITRO"

METHODS OF DETERMINATION OF THE DEGREE OF CYTOTOXICITY OF INDUSTRIAL DUSTS "IN VITRO"

https://doi.org/10.33573/ujoh2017.02.059

Lukianenko A. O.

METHODS OF DETERMINATION OF THE DEGREE OF CYTOTOXICITY OF INDUSTRIAL DUSTS "IN VITRO"

Paton Electric Welding Institute of National Academy of Sciences of Ukraine, Kiev

Full article (PDF), RUS

Background. Along with the search for effective methods of dusting and biological methods of preventing dust lung diseases problems of forecasting the harmful effects of industrial aerosols on the body remains rather actual, as well as the development of less labor-intensive and costly express methods for screening assessment of the toxicity of welding fumes.

The aim of the study. To ground the necessity of developing a method of express assessment of the toxicity of welding fumes. Materials and methods. There have been conducted a review of scientific publications, using world and national sources, the databases of the PubMed, National medical library and Vernadsky National Library of Ukraine.

Results. The methods of determining the toxicity of industrial aerosols have been considered. The necessity to develop an express method for assessment of the toxicity of welding fumes has been grounded. A new express method of determining the toxicity, using affordable, cheap and standard biological materials makes it possible to investigate the unsterile extracts and receive results for a period not exceeding 3 hours.

Conclusions. A new method of assessing the toxicity can broaden the possibilities to prognosticate cytotoxic properties of welding fumes, which are composed of highly toxic components of a wide spectrum.

Key words: in vitro methods, working zone air, cytotoxicity, industrial dust, welding fumes

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