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TOXICOLOGICAL ASSESSMENT OF INHALATION EXPOSURE TO HYPOGLYCEMIC DRUGS - DERIVATIVES OF SULPHONILUREA AS HARMFUL FACTORS OF THE WORK ENVIRONMENT

TOXICOLOGICAL ASSESSMENT OF INHALATION EXPOSURE TO HYPOGLYCEMIC DRUGS - DERIVATIVES OF SULPHONILUREA AS HARMFUL FACTORS OF THE WORK ENVIRONMENT

https://doi.org/10.33573/ujoh2008.03.041

Kudrya M.J., Palagina I.A., Ustenko N.V., Melnikovskaya N.V.

TOXICOLOGICAL ASSESSMENT OF INHALATION EXPOSURE TO HYPOGLYCEMIC DRUGS - DERIVATIVES OF SULPHONILUREA AS HARMFUL FACTORS OF THE WORK ENVIRONMENT

S.I. «V.Y.Danilevskiy Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine», Kharkov

Full article (PDF), RUS


The paper presents the results of the experimental study on peculiarities of the toxic effect of two hypoglycemic drugs, Glybenclamide and Glyclaside (derivatives of sulphonilurea), in conditions of an acute inhalation exposure. It is shown that Glybenclamide can cause a significant hypoglycemic effect, and Glyclaside is capable to disorder the prooxidant-antioxidant balance in the lung tissue. These effects are provided by peculiarities of both its specific pharmacologic and side effects. The threshold concentrations, that were established with due account of the criteria of toxicity, were used for hygienic standard-ization of these drugs in the working zone air.

Key words: hypoglycemic drugs, acute inhalation, threshold concentrations, hygienic standardization

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