4(37) 2013

DOI xxxxxxxx

Basanets A. V., Ostapenko T. A., Lubyanova I. P.

BIOMARKERS IN OCCUPATIONAL DISEASES: MODERN APPROACHES TO PNEUMOCONIOSIS DIAGNOSTICS

SI «Institute for Occupational Health of NAMS of Ukraine», Kyiv

Full article (PDF), UKR

Background. Pneumoconioses, occurring under exposure to different kinds of dusts, are among the most spread occupational diseases in Ukraine: about 2000 new cases of such diseases are diagnosed annually. They are diagnosed mostly at the later stages, when complications are developing. At these stages lung insufficiency, progressive pathological symptoms and invalidi- zation of the suffered are recorded.
Purpose of the study. To improve methods of early diagnostics and prevention of pneumoconiosis.
Materials and methods. There have been examined 543 patients with pneumoconiosis, exposed to coal dust and 187 persons of the control group. In order to study the state of health of workers of asbestos-cement enterprises there have been examined 276 individuals of main professions, exposed to dust, containing chrysotile asbestos. The study included clinical examinations, instrumental and laboratory methods, mathematical processing of the obtained data.
Results. The data on development and introduction into practice of specific biomarkers of early diagnostics of pneumoconio¬sis as a result of exposure to coal dust and asbestos, including High Resolution Computer Tomography and respirosonography signs, indices of static lung volumes, diffusion capacity of alveolar-capillary membrane, genetic markers of predisposition are presented in the article.

Key words: occupational diseases, respiratory system, pneumoconiosis, asbestosis, High Resolution Computer Tomography, bodyplethismography, diffusion capacity of alveolar-capillary membrane, genotype

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