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DETERMINATION OF CRITERIA OF THE TOXIC EFFECT OF SOME ANTI-DIABETIC MEDICINES FOR THEIR HYGIENIC REGULATION

DETERMINATION OF CRITERIA OF THE TOXIC EFFECT OF SOME ANTI-DIABETIC MEDICINES FOR THEIR HYGIENIC REGULATION

https://doi.org/10.33573/ujoh2007.01.031

Palagina I A., Kudrya M.Ya., Kolodub F.A., Karpenko N.O., Kozar V.V., Kavok N.S., Ustenko N.V.

DETERMINATION OF CRITERIA OF THE TOXIC EFFECT OF SOME ANTI-DIABETIC MEDICINES FOR THEIR HYGIENIC REGULATION

Institute of Endocrine Pathology Problems of AMS of Ukraine, Kharkov

Full article (PDF), UKR

The effect of anti-diabetic drugs Phcnsuccinal and Diacamph on the whole body and on its specific organs and systems with due account of changes of integral, functional, metabolic and immune indices in rats was studied in inhalation exposures. The criteria of inhalation toxicity of these drugs were established (disorders in pro-oxidant-antioxidant homeostasis and in the state of non-specific resistance). These criteria have been recommended for establishing threshold concentrations and hygienic regulation of anti-diabetic compounds with anti-oxidant activity.

Key words: anti-diabetic drugs, inhalation exposure, criteria of toxicity, pro-oxidant-antioxidant homeostasis, non-specific resistance, hygienic regulation

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