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Andrushchenko T. A., Basanets A. V.


SI "Institute for Occupational Health of the NAMS of Ukraine", Kyiv

Full article (PDF), UKR

Introduction. Actual occupational factors in coal mines in Ukraine, causing exogenous DNA damage in miners, are discussed in the paper, which can result in increasing mutation rates and in the DNA repair system disorders.

Purpose of the study. To analyze causes of exogenous disorders in the DNA repair system.

Materials and methods. An analytical review of scientific publications is made, using abstract databases of scientific libraries and textual databases of medical and biological publications in Pub Med.

Results. An analysis of the effect of occupational factors on miners, which can cause exogenous DNA damage, has been made. Different types of disorders of the DNA repair, repair mechanisms and their biological significance have been considered. The most studied gene polymorphisms, which are associated with disorders of the DNA repair, are mentioned.

Conclusion. The actuality of this scientific study is to determine the influence of occupational factors on disorders of the repair system, depending on individual susceptibility.

Key words: occupational factors, coal miners, exogenous DNA damage, DNA repair system


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