https://doi.org/10.33573/ujoh2005.02.033

Leonenko N.S.

EFFECT OF LOW DOSES OF CHLORSULFURON ON UPIO PEROXIDATION AND PROTEIN OXIDATIVE MODIFICATION IN RATS IN SUBCHRONIC EXPERIMENTS

Institute for Occupational Health of AMS of Ukraine, Kyiv

Full article (PDF), UKR

Results of the research of the effect ofchlorsulfuron on lipid peroxidation (LP) and oxidative modification of proteins (OMP) are presented in the paper. It was found that the effect of daily low doses of chlorsulfuron for 30 days caused changes in lipid peroxidation and oxidative modification of proteins. The modifications were of dose-dependent character. Changes of LP and OMP came to the norm within the period of recovery.

Key words: sulfonilurea herbicides, chlorsulfuron, oxidative modification of proteins, lipid peroxidation

References

  1. Gatsko R.G.. Mazhul' L.M.. Pozdnyakova Ye.A. Perekisnoye okisleniye lipidov v tkanyakh krys raznogo vozrasta v norme i pri golodanii/, Bul. eksper. biol. i med., 1982,-No 4, 30-32.
  2. Hryhor'yeva N.P.. Premiy I.M.. Meshchyshen I.F. Okysnyuvalna modyfikatsiya bilkiv ta aktyvnist deyakykh antyoksydantnykh fermentiv krovi shchuriv za umov oprominennya ta diyi nastoyanky arniky hirskoyi, Med. khim.,2000.- Vol2, No І. 70-73.
  3. Dubinina O.YU. Okysnyuvalnyy stres i okysnyuvalna modyfikatsiya bilkiv, Med. khim.- 2001, Viol З, No 2, 5-12.
  4. Zhuravleva T.D.. Suplotov S.N.. Kiyanyuk N.S. i dr. Vozrastnyye osobennosti svobodnoradikal'nogo okisleniya lipidov i antioksidantnoy zashchity v eritrotsitakh zdorovykh lyudey, Klin. lab. Diagnostika,-2003, No 8, 17-18.
  5. Kamyshnikov V.S. Spravochnik po kliniko-biokhimicheskoy laboratornoy diagnostike: v 2 t. Vol.2.- Minsk: Belarus'. 2000.119/5000
  6. Lyubinskaya L.A.. Povyakel' L.I. Toksikologicheskaya kharakteristika proizvodnykh sul'fonilmocheviny. http://www.medved.kiev.ua/arhlvte/22000.htm.
  7. Lyubinskaya L.A.. Povyakel' L.I. Bardik YU.V. Vliyaniye proizvodnykh sul'fonilmochevin na gormo¬nal'nyy status organizma teplokrovnykh zhivotnykh//Conf. « Actual problems of toxicology, hygiene and analytical chemistry of pesticides and agrochemicals: Abstractrs.- http://www.medved.kiev.ua
  8. Meshchyshen I.F. Metod vyznachennya okyslyuvalnoyi modyfikatsiyi bilkiv plazmy (syrovatky) krovi/ Bukov. med. visn., 1998.- Vol.2, No 1, 156-158.
  9. Meshchyshen I.F.. Polovyy V.P. Mekhanizm okyslyuvalnoyi modyfikatsiyi bilkiv/. Bukov. med. visn - 1999. Vol.З, No, 196-205.
  10. Perelik pestytsydiv i ahrokhimikativ, dozvolenykh do vykorystannya v Ukrayini [List of pesticides and agrochemicals authorized for use in Ukraine], Univest Marketing, Kyiv, 2003.
  11. Tumochko M.F.. Kobylinska L.1. Vilnoradykalni reaktsiyi ta yikh metabolichna rol //Med. lim.- 1999. Vol.1, No1, 19-25.
  12. Ellman G.L. Tissue sulfhydryl groups//Arch. Bio- chem. Biophys.- 1959.- V.82.-P. 70-76. https://doi.org/10.1016/0003-9861(59)90090-6
  13. IPCS Environmental Health Criteria 170. Asses­sing human health risk of chemicals: derivation of guid­ance value for health-based exposure limits.- Geneva: WHO. 1994.-73 p.
  14. The Pesticide Manual/9th ed./British Crop Pro­tection Council. 1991