Kostyshyn N. M., Grzhegotsky M. R., Servetnyk M. I.
EVALUATION OF STRUCTURAL AND FUNCTIONAL STATE OF RAT’S BONE TISSUE UNDER WHOLE BODY VIBRATION
Danylo Halytsky Lviv National Medical University
Full article (PDF), UKR
Introduction. The influence of whole body vibration can affect the bone tissue and the body in general, intensifying the development of pathological processes, caused by the negative effect of the environment. Vibration exposure can result in adverse health effects such as spinal injuries, abdominal, neurological and cardiovascular disorders. Experiments on animals show remodeling bone changes in response to the low-frequency whole body vibration, but the data on the middle and high frequency of occupational vibration are limited.
Purpose of the study was to conduct studying the effect of whole body vibration of different frequencies on the structural and functional state and on mechanisms of bone remodelling in rats.
Materials and methods. An experimental study was conducted on mature male rats. Fragments of rats’ femoral bone were taken for histologic examination.
Results. In all experimental groups the relationship between the power of the vibration stimulus and the level of the metabolism of bone tissue was found. In the course of the histological study of specimens of the bone tissue on the 28th day of the experiment acute damages in the bone tissue and initial signs of its remodeling have been seen. The remodelling processes in the bone and initial manifestations of the osteogenesis reach their maximum in animals after ceasing the vibration exposure. Тhe remodeling processes were represented by enhanced regeneration in the zone of the cartilage plate, increased proliferation activity and hyperplasia of chondrocytes, hypertrophy in the respective zones of the cartilage tissue, by zones of forming immature bone tissue in areas of the previous damage, focal replacement fibrosis and angiomatosis.
Conclusion. It has been determined that with the increase of the vibration frequency (from 15 Hz to 75 Hz) the velocity of the bone tissue metabolism increases, osteoblasts’ activation processes are observed, the impairment of collagen and calcium losses is increased, leading subsequently to the osteoporosis occurrence.
Key words: whole body vibration, bone tissue, bone remodeling
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