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HYGIENIC CRITERIA OF BRONCHI AND LUNGS CANCER OF OCCUPATIONAL ORIGIN IN PATIENTS EXPOSED TO CRYSTAL SILICA

HYGIENIC CRITERIA OF BRONCHI AND LUNGS CANCER OF OCCUPATIONAL ORIGIN IN PATIENTS EXPOSED TO CRYSTAL SILICA

3(22) 2010

https://doi.org/10.33573/ujoh2010.03.003

Varyvonchyk D. V., Remennyk О. L.

HYGIENIC CRITERIA OF BRONCHI AND LUNGS CANCER OF OCCUPATIONAL ORIGIN IN PATIENTS EXPOSED TO CRYSTAL SILICA

SI «Institute for occupational health of AMS of Ukraine», Kyiv

Full article (PDF), UKR

A 25-year retrospective epidemiological study of bronchi and lungs cancer (BLC) in patients with pneumoconiosis (PC), chronic bronchitis (CB), chronic obstructive lungs disease (COLD) exposed at workplace to dust — coal-mining rock (CMR) and production rock (PR) with the content of crystal SiO2 (quartz) has been conducted. The risk of BLC development increased when the period of work exposure to Si02 was more than 15 years (latent period from 20 to 40 years, including a post-exposure period — by 20 years). The minimum threshold of the cumulative inhalation of SiO2 entering for development of PC, CB, COLD makes 85,0 life-years; for BLC: PR - 200,0 life-years (OR = 4,2 [CI95 % 3,9—4,8, p < 10-3]), CMR - 400,0 life-years (OR = 3,0 [CI95 % 1,48-3,00, p < 10-3]). A carcinogenic potential (CSFi) for occupational exposure to dust containing SiO2 makes: for PR — 0,047 (mg/(kg • d))-1; for CMR — 0,028 (mg/(kg • d))-1, which exceeds the population index by 93,3—157,0 times.

Keywords: SiO2, work conditions, cancer potential, bronchi and lungs cancer

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