3(22) 2010

DOI xxxxxxxx

Varyvonchyk D. V., Remennyk О. L.

HYGIENIC CRITERIA OF BRONCHI AND LUNGS CANCER OF OCCUPATIONAL ORIGIN IN PATIENTS EXPOSED TO CRYSTAL SILICA

SI «Institute for occupational health of AMS of Ukraine», Kyiv

Full article (PDF), UKR

A 25-year retrospective epidemiological study of bronchi and lungs cancer (BLC) in patients with pneumoconiosis (PC), chronic bronchitis (CB), chronic obstructive lungs disease (COLD) exposed at workplace to dust — coal-mining rock (CMR) and production rock (PR) with the content of crystal SiO2 (quartz) has been conducted. The risk of BLC development increased when the period of work exposure to Si02 was more than 15 years (latent period from 20 to 40 years, including a post-exposure period — by 20 years). The minimum threshold of the cumulative inhalation of SiO2 entering for development of PC, CB, COLD makes 85,0 life-years; for BLC: PR - 200,0 life-years (OR = 4,2 [CI95 % 3,9—4,8, p < 10-3]), CMR - 400,0 life-years (OR = 3,0 [CI95 % 1,48-3,00, p < 10-3]). A carcinogenic potential (CSFi) for occupational exposure to dust containing SiO2 makes: for PR — 0,047 (mg/(kg • d))-1; for CMR — 0,028 (mg/(kg • d))-1, which exceeds the population index by 93,3—157,0 times.

Key words: SiO2, work conditions, cancer potential, bronchi and lungs cancer

References

  1. Varyvonchyk D. V. Ryzyky zakhvoryuvanosti na zloyakisni novoutvorennya bronkhiv ta lehenʹ u khvorykh iz khronichnym bronkhitom ta pnevmokoniozom / D. V. Varyvonchyk, O. I. Remennyk, V. M. Isypova // Ukr. zhurn. z problem med. pratsi.- 2010.- № 1.- S. 16-20.
  2. Varyvonchyk D. V. Do problemy etiolohiyi ta profilaktyky raku bronkhiv ta lehenʹ, sered robitnykiv eksponovanykh na vyrobnytstvi pylom dvookysu kremniyu / D. V. Varyvonchyk // Ukr. zhurn. z probl. med. pratsi.- 2008.- № 2.- S. 69-81.
  3. Rukovodstvo po otsenke ryska dlya zdorovʹya nase­lenyya pry vozdeystvyy khymycheskykh veshchestv, zahryaznyayushchykh okruzhayushchuyu sredu : R 2.1.10.1920-04.- M., 2004.- S. 124-134.
  4. Finkelstein M. M. Silica, silicosis, and lung cancer: a risk assessment / M. M. Finkelstein // Am. J. Ind. Med.- 2000.- V. 38, № 1.- P. 8-18.
  5. Goldsmith D. F. Comparative cancer potency for silica from extrapolations of human and animal findings / D. F. Goldsmith, R. P. Ruble, C. O. Klein // Scand. J. Work. Environ. Health.- 1995.- V. 21, S. 2.- R 104-107.
  6. Silica (crystalline, respirable) // Chronic Toxicity Summary.- 2005.- 48 p.
  7. Silica // IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.- 1997.- V. 68.- 41 p.