2(39) 2014

DOI xxxxxxxx

Karlova O. A.1, Sheiman B. S.2

INVESTIGATION OF ENDOGENOUS INTOXICATION IN PATIENTS EXPOSED TO LEAD

1O. O. Bogomolets National Medical University, Kyiv
2National Children's Hospital «Okhmatdyt''of Ministry of Health of Ukraine», Kyiv

Full article (PDF), UKR

Introduction. Among numerous diagnostic methods, using to determine an endogenous intoxication, the calculated indices became the most commonly used in clinical practice, such as leukocytic (LI), hematological (HI) and nuclear (NI).
The aim of research. To study the informativeness of calculation methods for verifying the endogenous intoxication in patients exposed to lead, depending on the content of lead in blood.
Materials and methods. The investigations of endotoxemia, using calculation indices of intoxication (nuclear, hematological and leukocytic) were conducted in 146 wiremen, exposed to lead in concentration exceeding TLV by 1,4—1,8 times (main group) and in 57 workers of the control group. At the same time levels of toxin-induced autoimmune reactions (TIAR), toxin- induced cytological responses (TICR) of blood plasma and concentrations of lead in their blood (Pb-K) have been analyzed. In order to assess anti-toxic adapt systems in all workers index of reaction (IR ) of a systemic response, index of sensitization (IS), index value of neutrophils and lymphocytes (ISNL) and index of relation of lymphocytes and eosinophils (IRLE) were defined.
Results. Studies have shown that the increase of the Pb-K in workers exposed to lead are accompanied by a statistically sig-nificant increase of the calculated indices of endogenous intoxication as well as indices, determining the increase in activity of toxin-induced autoimmune reactions and toxin-induced cytolytic responses (TICR) in blood plasma.
Conclusions.The manifestations of endogenous intoxication in workers, exposed to lead, are characterized by changes in the calculated indices: LII, HII, NII and TIAR and TICR. In this, development of endogenous intoxication in workers is deter¬mined by the formation of significant correlations between the concentration of coproporphyrin in urine and TIAR albumin and TICR freely-circulating toxins.


Key words: lead, leukocyte index of intoxication, specific features of endotoxemia development

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