https://doi.org/10.33573/ujoh2005.02.041

Dmytrukha N.N.1, Lugovskyi S.P.2

INVESTIGATION OF IMMUNE PROCESSES INVOLVING INTO DEVELOPMENT OF LEAD ACETATE TOXIC EFFECT ON THE KIDNEYS OF WHITE RATS

1 Institute for Occupational Health of AMS of Ukraine, Kyiv,

2 Institute of Industrial Medicine Kryvyj Rig

Full article (PDF), UKR

The lead intoxication was simulated in male white rats. The state of body nonspecific resistance was assessed in rats after 25 intraperitonial injections of lead acetate at the dose of 2.5 mg/kg body weight. It was established the change of the phagocyt¬ic activity and oxidative-reduction processes in blood neutrophyles, high level of immune complexes in blood serum of ex-perimental animals as compared with the control. Histological studies show changes in kidney structural components with immune complexes deposits in the capsule cavity of kidney bodies, on the walls of capillaries of kidney balls and in arteries of the cerebral laye. The changes of immunological indexes of the peripheral blood in the rats exposed to lead is likely to be con-sidered as early criteria of lead toxic effect on the body and also be acknowledge of the participation immune processes in for-mation of kidney pathology in lead intoxication.

Key words: lead acetate, immunotoxicity, lead intoxication

References

  1. Biletska E.M. Hihiyenichni aspekty vazhkykh metaliv u navkolyshnomu seredovyshchi//Bukovynskyy med. visn.- 1999.- Vol. 3, No 2, 207-211.
  2. Gandzha I.M.. Myagkaya I.P.. Sakharchuk V.M. i dr. Sistema immuniteta pri zabolevaniyakh vnutrennikh organov.- K.: Zdorov'ya. 1985.- 280 s.
  3. Gil'denskiol'd R.S.. Novikov YU.V..Khamiduli R.S. Tyazhelyye metally v okruzhayushchey srede i ikh vliyaniye na organizm (obzor)//Gig. i san.- 1992.- No 5-6, 6-9.
  4. Nasonov Ye.L.. Sura V.V. Vzaimosvyaz autoimmunnoy i immunokompleksnoy patologii: sovremennoye sostoyaniye problemy//Terapevt, arkh.- 1984, LVI, No 10, 4-9.
  5. Zabrodskiy P.F. Mekhanizmy toksicheskogo deystviya metallov i ikh vliyaniye na immunnuyu sistemu//Toksikol. vesti.- 1998, No 6, 9-15.
  6. Ivanova M.M.. Nasonova Ye.L.. Solov'yev S.K. i dr. Tsirkuliruyushchiye immunnyye kompleksy (PEG-testy) pri sistemnoy krasnoy volchanke//Terapevt. arkh,- 1982.-No 6, 63-68.
  7. Kundiev Yu.I., Trakhtenberg I.M. (1991), “Ecological and hygienic aspects of the problem of heavy metals as technogenic pollutants “, Gigiena truda, Issue 27, 3-8.
  8. Mikroskopicheskaya tekhnika: Rukovodstvo/Pod red. D.S.Sarkisova. YU.L.Perova.- M.: Meditsina. 1996 - 544 s.
  9. Mintser O.P., Ugarov B.N., Vlasov V.V. Metody obrabotki meditsinskoy informatsii.- K.: Vyshcha shkola, 1991.-271 s.
  10. Obshchaya toksikologiya/Pod red. B.A.Kurlyandskogo. V.A.Filova.- M.: Meditsina. 2002,- 608 s.
  11. Paran'ko N.M.. Belitskaya E.N.. Karnaukh N.G. i dr. Tyazhelyye metally vneshney sredy i ikh vliyaniye na immunnyy status naseleniya,- Dnepropetrovsk: Polígrafíst. 2002.- 143 s.
  12. Paster Ye.U., Ovod V.V.. Pozur V.K. Immunologiya.-K.: Vyshcha shkola,. 1989.-284 s.
  13. Rudyk B.I.. Baranovskiy P.V. Sravnitel'naya otsenka izucheniya soderzhaniya immunnykh kompleksov pri infarkte miokarda, bronkhial'noy astme i revmatoidnom artrite//Terapevt, arkh.- 1984,- LVI, No 10, 17-19.
  14. Sepiashvili R.I. Vvedeniye v immunologiyu.- Tskhaltubo-Kutaisi. 1987,-230
  15. Stezhka VA, Dmitrukha N.N. Pokrovskaya T.N. et al. (1998), “Comparative assessment of the lead's immunotoxic effect on neutrophilic leukocytes and peripheral blood lymphocytes of rats in in vivo and in vitro experiments “, Problemy med. pratsi, 149-159.
  16. Trakhtenberg I.M. (1997), “Heavy metals as chemical pollutants of work-related and ambient environmental “, Dovkіllya i zdorovya, No 2, 48-51.
  17. Ugryumov M.V. Sovremennyye metody immunotsitokhimii i gistokhimii. Itogi nauki i tekhn. VINITI. Ser. Morfologiya,- 1991.-T.15.- 115 s.
  18. Bellon В. et al. Mercuric chloride induced autoimmune disease in Brown- Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes//Eur. J. Clin. Invest.- 1982.-No 12.-P. 127-133. https://doi.org/10.1111/j.1365-2362.1982.tb00949.x
  19. Carlo J.R., Ruddy S., Conwey A.E. Localizаtion of the receptors activated complement on the visceral epithelial cells of the human renal glomerulus by immunoenzymatic microscopy//Am. J. Clin. Pathol.- 1981.- No 1.- P. 23-27. https://doi.org/10.1093/ajcp/75.1.23
  20. Immunotoxicity of metals and immunotoxlcolo gy. Proceedings of an International Workshop/Ed. by A.D.Deyan et al.- New York. London: Plenum press. 1990.-316 p.
  21. Haskova V., Kaslik J., Riha I. et al.//Z. Immun.- Forsch.- 1978,- Bd. 154.- S. 399-406. https://doi.org/10.1016/S0340-904X(78)80012-8
  22. Lawrence D.A.. Mudzinsky S.. Rudovsky U. Me­chanisms of metal-induced immunotoxicity in immunotoxicology/Ed. by A.Berlin. J.Dean, M.N.Draper et al., 1987. - P. 293-303. https://doi.org/10.1007/978-94-009-4307-0_21
  23. Toxikological Profile for Lead. Draft for Public Comment/Comment Period Ends: February 17. 1998. - 483 p.