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Modern approaches to nanomaterial testing and regulation

Modern approaches to nanomaterial testing and regulation

ISSN 2223-6775 Ukrainian journal of occupational health Vol.15, No 4, 2019

Modern approaches to nanomaterial testing and regulation

Lugovskiy S. P., Demetska O. V., Tsapko V. G.

State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv

https://doi.org/10.33573/ujoh2019.04.263

Full article (PDF), UKR

Introduction. Today, there are a number of obstacles to effective assessment of nanoparticles and nanomaterials on safety and their environmental impact. The problem of rationing the nanotechnology products also remains open.

The purpose of research To analyze current strategies for testing and rationing nanomaterials and determine the main questions, answers to which will help to improve risk assessment and to reduce potential risks to people and the environment.

Materials and methods of research. The analysis of legal regulation in the field of nanotechnology and scientific publications on testing and standardization of nanoparticles and nanomaterials was made, using WHO, ILO, and PubMed electronic resources and databases by a bibliosemantic method.

Results. The safety of nanomaterials can be provided by conducting animal tests only in extreme cases. The lack of adequate physicochemical characteristics of nanoparticles limits the reliability of the results of toxicological studies. A hazard assessment of each variant of the nanomaterial is impossible and undesirable by economic reasons. Scientifically based approaches to the grouping of nanomaterials make it possible to predict the toxicity of a substance by comparing it with other similar substances.

Conclusions. Reliable and complete characterization of the material is a prerequisite for initiating toxicity studies. In such studies, the use of laboratory or exotic nanoparticles and / or those in high doses should be avoided. The development of the standardized in vitro methodological approaches is needed. Nanoparticles, as a side process of non-nanotechnological production processes, are not subject to hygienic regulation. In order to establish temporary settlement regulations for nanomaterials, safety coefficients can be used and a nanomaterial grouping approach.

Key words: nanomaterials, nanoparticles, testing, regulation

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