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4(37) 2013

DOI xxxxxxxx

Trakhtenberg I. M., Dmytrukha N. M.


SI «Institute for Occupational Health of NAMS of Ukraine», Kyiv

Full article (PDF), UKR

Background. Intensive studies on nanoscience and on implementation of the results of nanotechnologies into practice of human activity are conducted all over the world, including Ukraine.
Purpose. To study and generate the data of the world literature, covering also personal investigations, regarding the general characteristics of nanoparticles of metals, toxic properties and spheres of use.
Methods. An analytical review of scientific publications, using the databases of Portalnano, PubMed and Vernadsky National library of Ukraine, generation of the data.
Results. The characteristics of nanoparticles of metals is given, covering, also, methods of their definition, spheres of use and properties.
Conclusion. Metal compounds in the form of nanoparticles have physical, chemical properties and can cause toxic effects in comparison with their micro- and ionic forms. Their toxicity depends on such characteristics, as size, structure, square of the surface, type of the metal, method of definition and a biological model, which is used in the study.

Key words: nanomaterials, nanotoxicology, metals nanoparticles, biosafety


  1. Balabanov, V. I. 2009, Nanotechnology, Science of future. M.: Eksmo, pp. 215-220 (in Russian).
  2. Chekman, I. S. 2009, «Nanoparticles: Properties and prospects of use», Ukrainian bichemical journal, Vol. 81, no.1, pp. 122-129 (in Ukrainian).
  3. Sitar O., Novitsky, N. V., Taran, N. Yu. et al., 2010, «Nanotechnology in modern agriculture», Physics of living, Vol. 18, pp. 113-116 (in Ukrainian).ISO/TS 11360: 2010. Nanotechnologies -
  4. Methodology for the classification and categorization of nanomaterials, Ed. 2010 -07-15. 32 p.
  5. 5. Chekman, I. S., Serduk, A. M., Kundiyev, Y. I., Trakhtenberg, I. M. et al. 2009, «Nanotoxicology: directions of research (Review)», Environment and Health, no. 1 (48), pp. 3-7 (in Ukrainian).
  6. 6. State scientific and technological program «Nanotechnologies and nanomaterials» for 2010-2014 (Decree of the Cabinet of Ministers of Ukraine of 28 October 2009, № 1231), 2009, Official Heald of Ukraine, no. 90, 9 p.
  7. Kartel, M. T., Tereschenko, V. P. 2008, «The concept of the methodology of identification and toxicological studies and risk assessment of nanomaterials for human health and the environment in their production and use», Chemistry, Physics and Technology surface. Kiev: Naukova Dumka, Issue 14, pp. 565-583 (in Ukrainian).
  8. Prodanchuk, N. G., Balan, G. M. 2009, «Nano- toxicology: Status and prospects of research», Modern problems of toxicology, no. 3-4, pp. 4-18 (in Russian).
  9. Pavlyho, T. N., Serduk, G. G. 2010, «Classification of nanomaterials in international standardization», Nanostructural science of materials, no. 4, pp. 92-99 (in Ukrainian).
  10. 10. Andrusishina, I. N. 2011, «Metal nanoparticles: methods of detection, physical and chemical properties, methods of research and evaluation of toxicity», Modern problems of toxicology, no. 3, pp. 5-14 (in Russian).
  11. Volkov, S. V., Kovalchuk, S. P, Henko, V. M., Reshetniak, O. V. 2008, Nanochemistry. Nanosystems. Nanomaterials. Kyiv: Naukova Dumka, 422 p. (in Ukrainian).
  12. Borisevich, V. B., Kaplunenko, V. G., Kosinov, N. V. [et al.]. 2012, Nanomaterials and nanotechnology in veterinary practice. K.: Avitsena, 512 p.
  13. Rayevska, O. E., Grodzyuk, G. Ya., Dzhagan, V. M., Stroyuk, O.L., Kuchmiy, S.vYa., Plyusnin, V. F., Gri- vin, V. P., Valakh, M. Ya. 2010, «Synthesis and char acterization of white-emitting CdS quantum dots stabilized with polyethylenimine», J. Phys. Chem.,V. 114, no. 51, pp. 22478-22486.
  14. Shahverdy, A. R., Fakhimi, Ali, Minaian, Sara, 2007, «Synthesis and effect of silver nanopracles on the antibacterial activity of different antibiotics against Staphylococcus and Escherichia coli», Nanovedicine- Nanotechnology biology and medicine, Vol. 3 (2), pp. 168-171.
  15. Alt, V., Bechert, Th., Steinrucke, P. et al. 2004, «An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement», Biomaterials, Vol. 25 (18), pp. 4383-4391.
  16. Braydich-Stolle, L., Hussain, S., Schlager, J. 2005, «Cytotoxicity of nanoparticles of silver in mammalian cells», Toxicological Sciences, Vol. 3, no. 2, pp.38-42.
  17. Ji, J.H. 2007, «Twenty-eight-day inhalation toxicity study of silver nanoparticles in Sprague-Dawley rats», Inhalation Toxicology, Vol. 19, no. 10, pp. 857-871.
  18. Susan, W. P. Wijnhoven, Willie, J. G. M. Peijnen- burgb; Carla A. Herberts et al. 2009, «Nano-silver - a review of available data and knowledge gaps in human and environmental risk assessment», Nanotoxicology, Vol. 3, no. 2, pp.109-138.
  19. Dykman, L. A., Bogatyrev, V. A., Goldfinches, S. Y. et al. 2008, Gold nanoparticles: synthesis, properties and biomedical use. Moscow: Nauka, 319 p. (in Russian).
  20. Suleimanova, L. V. 2009, «Morphological changes of organs and tissues in experimental animals, exposed to nanoparticles of gold», Abstract. Thesis, dissert. cand. med.sci. 14.0015., Saratov, 24 p. (in Russian).
  21. Dybkova, S. M., Reznichenko, L. S., Gruzina, T. F., Ulberh, Z. R. 2010, «Assesment in vivo DNA-damaging action of gold nanoparticles of different size», Biotechnology, Vol. 3, no. 3, pp.66-71 (in Ukrainian).
  22. Kovalenko, L. V., Folmanis, G. E. 2006, Dietary iron nanopowders. Moscow: Nauka, 124 p. (in Russian).
  23. Kazneselson, B. A., Privalova, L. I., Kuzmin, S. et al. 2010, «The experimental data for estimatation of pulmonotoxicological and resorptive toxicity of magnetite particles (Fe3O4) of nano-and micrometer size, Journal of Toxicology, no. 2, pp. 17-24 (in Russian).
  24. Lizeng Gao, Jie Zhuang, Leng Nie 2007, «Intrinsic peroxidase-like activity of ferromagnetic nanoparticles», Nanotechnology, Vol. 2, no. 9, pp. 577-583.
  25. Heinlaan, M., Ivask, A., Blinov, I. et al. 2008, «Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus», Chemosphere, Vol. 71, no. 7, pp. 1308-1316.
  26. Chen, Z., Meng, H., Hing, G. 2006, «Acute toxicological affects of copper nanoparticles in vivo», Toxicology Letters, Vol. 163, pp. 109-120.
  27. Wang, B. 2006, «Acute toxicity of nano- and microscale zinc powder in healthy adult mice», Toxicology Letters, Vol. 161, no. 2, pp. 115-123.
  28. Kang, S. J. 2008, «Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes», Environmental Molecules Mutagens, Vol. 49, no. 5, pp. 399-405.
  29. Wang J., Zhou G., Chen C. 2007, «Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration», The journal of phisical chtmistry, Vol. 168, pp. 176-185.
  30. Chen, H. W., Su, S. F., Chien, C. T., Lin, W. H. 2006, «Titanium dioxide nanoparticles induse emphysema-like lung injury in mice», FASEB J., no. 20, pp. 2393-2395.
  31. Chen, L. 2008, «Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculare», J. Neuroimmune Pharmacology, Vol. 3, no. 4, pp. 286-295.
  32. Knirsch, W., Kern, K., Schleh, C., Adelhelm, C. 2006, «Nanoparticulate vanadium oxide potentiated vanadium toxicity in human lung cells», Environ. Scin. Technol., Vol. 41, no. 1, pp. 331-336.
  33. Hardman, R. 2006, «A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors», Environ. Health Perspective, Vol. 114, no. 2, pp. 165-172.
  34. Wasana Senevirathna, Ruth Kiro, Rachel Rosen, et al. 2009, «CdSe quantum dots induce superoxide stress in engineered biosensor bacteria», Nanotoxicology, Vol. 3, no. 2, pp. 98-108.
  35. Korolenko, T., Dmytrukha, N., Marchenko, M. 2010, «Assessment of biological activity of Cu, Zn, Fe, Mg citrates, produced in nanotechnology by in vitro studies», Book of abstracts of Ukrainian-German symposium on physics and chemistry of nanostructures and nanobiotechnology, Beregove, The Crimea, Ukraine, 6-10 September, 2010, pp. 257.
  36. Dmytrukha, N. M., Korolenko, T K., Marchenko, M. L. 2009, «Use of cell cultures in toxicological experiment», Modern problems of bioethics. Kyiv: Akademperiodika, pp. 166-171 (in Ukrainian).
  37. Marchenko, M. L., Bezdyenyezhnyh, N. A., Fahmy, M. 2011, «Study of cytotoxic metal nanoparticle in human cell culture experiments in vitro», Ukrainian Journal of Occupational Health, no. 1 (25), pp. 63-70 (in Ukrainian).
  38. Gubar, I. V., Ilchuk, O. S., Kupovska, S. I. et al. 2012, «The influence of lead micro-and nanoparticles on proteins in the system of blood coagulation in vitro», Tauride Medical and Biological Bulletin. Ukrainian scientific journal, Vol. 15, no. 1 (57), pp. 307-309 (in Ukrainian).
  39. Lubyanova, I. P., Krasnokutskaya, L. M., Dmyt- rukha, N. N. et al. 2011, «A non-invasive method for determining the accumulation of iron in the liver of rats with lead intoxication», Ukrainian Journal of Occupational Health, no. 3 (27), pp. 43-47 (in Russian).
  40. Apykhtina, E. L., Sokurenko, L. M., Chaikovsky Yu. B. et al. 2012, «Change of the content of fatty acids in brain tissues of animals after influence of nanoparticles of lead sulfide of different size», Sience and Education, December 18 th-19th 2012, Vol. II, pp. 438-442.