Joseph LaDou, M.O.


University of California School of Medicine, USA

Full article (PDF), ENG

Many governments offer incentives to microelectronics companies to locate in their regions. Most semiconductor chip manufac¬ture is taking place in Asia where occupational health research, protective standards, and enforcement are at unacceptably low levels. Moreover, the printed circuit board industry is now largely concentrated in Asia. Some American and European compa¬nies have expanded microelectronics manufacture in Central and Eastern Europe where it is hoped that higher standards of occu¬pational health and safety can be achieved.Occupational illnesses occur at a high rate in electronics workers, particularly among semiconductor workers. Microelectronics manufacture is done in cleanrooms where air is recirculated after dust is removed by particulate filters. Many different chemicals, metal dopants, and other materials are used in the semiconductor industry. The chemical fumes and vapors that are not removed by air filtration are recirculated with continuous worker exposure. The industry also presents problems of radiation exposure as well as a variety of occupational stressors, including ergonomic issues.

Key words: microelectronics, electronics, semiconductor, printed circuit board, cleanroom


  1. Fischman M.L.. Goldstein, D.A.. Cullen M.R. Emerging Technologies: Microelectronics Industry & Biotechnology// "textbook of Clinical Occupational and Environmental Medicine. 2nd ed./Ed. by L.Rosenstock et al.- Philadelphia: Elsevier Saunders. 2005.- P. 263-271.
  2. Pocekay D.. McCurdy S.A.. Samuels S.J. et al. A cross-sectional study of musculoskeletal symptoms and risk factors in semiconductor workers//Am. J. Ind. Med.- 1995.-V.28.-P. 861-871.
  3. Chee H.L.. Rampal K.G.. Chandrasakaran A. Ergonomic risk factors of work processes in the semi­conductor industry in Peninsular Malaysia//Ind. Health.- 2004,- V.42.- P. 373-381.
  4. Chee H.L., Rampal K.G. Work-related muscu­loskeletal problems among women workers in the semi­conductor industry in Peninsular Malaysia//Int. J. Occup. Environ. Health.- 2004,- V. 10,- P. 63-71.
  5. Survey of Occupational Injuries and Illnesses. 2004. U.S. Department of Labor. Bureau of Labor Statistics.
  6. McCurdy S.A.. Schenker M.B.. Samuels S.J. Reporting of occupational injury and illness in the semiconductor manufacturing industry//Am. J. Pub. Health.- 1991.-V.81 (Suppl. 1).-P. 85.
  7. LaDou J. International occupational health//Int. J. Hygiene Environ. Health - 2003,-V.206.- P. 303-313.
  8. Pastides H., Calabrese E.J.. Hosmer D.W.. Harris D.R. Spontaneous abortion and general illness symp­toms among semiconductor manufacturers//J. Occup. Med.- 1988.-V.30.- P. 543-551.
  9. Correa A.. Gray R.H.. Cohen R. et al. Ethylene glycol ethers and risks of spontaneous abortion and subfertllity//Am. J. Epidemiol.- 1996.-V. 143. №7,- P. 707-717.
  10. Schenker M.B.. Gold E.B.. Beaumont J.J. et al. Association of spontaneous abortion and other repro­ductive effects with work in the semiconductor indus­try//Am. J. Ind. Med.- 1995.-V.28.- P. 639-659.
  11. Vagero D.. Olin R. Incidence of cancer in the elec­tronics industry, using a new Swedish Cancer Environment Registry as a screening instrument//Br. J. Ind. Med.- 1983.-V.40.-P. 188-192.
  12. Beall C.. Delzell E., Cole P.. Brill I. Brain tumors among electronics industry workers//Epidemiol.- 1996-V.2.-P. 129.
  13. Thomas T.L., Stolley P.D.. Stemhagen A. et al. Brain tumor mortality risk among men with electrical and electronics jobs//J. Natl Cancer Inst.- 1987,- 2.- P. 233-238.
  14. Clapp R.W.. Johnson R.A. Mortality among U.S. employees of a large computer manufacturing company - 1969-2001. In preparation.
  15. HSE. Cancer among current and former workers at National Semiconductor (UK) Ltd. Greenock: results of an investigation by the Health and Safety Executive. 2001. London: Health and Safety Executive. UK: 2001.
  16. HSE: Inspections by the Health and Safety Executive in 2002 of manufacturers of semiconductors in Great Britain. Health and Safety Executive: London. Available at:
  17. Watterson A.. LaDou J. Phase 2. Health & Safety Executive inspection of U.K. semiconductor manufac- turers//lnt. J. Occup. Environ. Health.- 2003.-V.9. №4.
  18. LaDou J. Printed Circuit Board Industry//Int. J. Occup. Environ. Health.- 2006: in press.
  19. Environmental Protection Agency. Design for the Environment,
  20. Vincent R.. Rieger B.. Subra I.. Poirot P. Exposure Assessment to glycol ethers by atmosphere and biologi­cal monitoring//Occup. Hyg.- 1996.-V.2.- P. 79-90.
  21. Loh C.H.. Shih T.S.. Hsieh A.T. et al. Hepatic effects in workers exposed to 2-methoxy ethanol//J. Occup. Environ. Med.-2004.-V.46.-P. 707-713.
  22. Shih T.S.. Hsieh A.T.. Liao G.D. et al. Haematological and spermatotoxic effects of ethylene glycol monomethyl ether in copper clad laminate facto- ries//Occup. Environ. Med.- 2000.-V.57.- P. 348-352.
  23. Shih T.S.. Liou S.H.. Chen C.Y.. Chou J.S. Correlation between urinary 2-methoxyacetic acid and exposure of 2-methoxyethanol//Occup. Environ. Med.- 1999,-V.56.- P. 674-678.
  24. Shih T.S.. Hsieh A.T.. Chen Y.H. et al. Follow up study of haematological effects in workers exposed to 2- methoxyethanol//Occup. Environ. Med.- 2003.- V.60 (Suppl.2).- P. 130-135.
  25. Chang H.Y.. LinC.C.. ShihT.S. et al. Evaluation of the protective effectiveness of gloves from occupational exposure to 2-methoxyethanol using the biomarkers of 2-methoxyacetic acid levels in the urine and plas- ma//Occup. Environ. Med.- 2004.- V.61- P. 697-702.
  26. Chang Y.M.. Tal C.F.. Lin R.S. et al. A proportion­ate cancer morbidity ratio study of workers exposed to chlorinated organic solvents in Taiwan//!nd. Health.- 2003.-V.41.-P. 77-87.
  27. Steenland K.. Stayner L.. Deddens J. Mortality analysis in a cohort of 18.235 ethylene oxide exposed workers: follow up extended from 1987 to 1998// Occup. Environ. Med.- 2004.-V.61.- P. 2-7.
  28. Chen P.C.. Hsieh G.Y.. Wang J.D.. Cheng T.J. Prolonged time to pregnancy in female workers exposed to ethylene glycol ethers in semiconductor manufactur- lng//Epidemiol.- 2002.- V. 13.- P. 191-196.
  29. European Union. Directive 2002/95/EC of the European Parliament and of the Council of 27 January 2003 on the Restriction of the Use of Certain Hazardous Substances in Electrical and Electronic Equipment (RoHS).
  30. Thacker P.D. U.S. Companies Get Nervous about EU's REACH//Environmental Science and Technology Online. January 5. 2005. ner­vous. html
  31. California Department of Toxic Substances Control. Electronic Waste Recycling Act of 2003 (SB20)
  32. European Union. Directive 2002/96/EC of the European Parliament and of the Council of 27 January 2003 on Waste Electrical and Electronic Equipment (WEEE). 037/1 03720030213en00240038.pdf
  33. European Union. Directive 67/548/EEC on the Classification. Packaging and Labelling of Dangerous Substances. Annex 1. as last amended by Directive 2003/32/EC (28th ATP). http://env-heavymetalfree/Ind-pla-eff-saf-env-euleglslatlon.htm
  34. European Union. Directive 2000/53/EC of the European Parliament and of Council of 18 September 2000. End-of-life Vehicles. http://env-heavymetal- free/ind-pla-eff-saf-env-eu leglslation.htm