Martirosova V. G.1, Sorokin V. M.2, Nazarenko V. I.1, Dmitrukha N. N.1


1SI "Institute for Occupational Health of NAMS of Ukraine", Kiev

2Institute of physics of semiconductors named after Loshkarev V. E., Kiev

Full article (PDF), RUS

Introduction. LED sources of cold-white light with Tcolor = 4000 K and higher emit a powerful flux, ranging 400–500 nµ of the visible light, coinciding with the zone of the higher sensitivity (477 nµ) of new, recently discovered ganglion retina cells (GRC). Nervous ways of GRC are ended in the hypothalamus and affect the pineal gland secretion – melatonin hormone. It is supposed that the work in conditions of the light environment, equipped with cold-white lamps, can result in inhibition of melatonin secretion, influencing many endocrine processes in the body. The studies, conducted by the authors, showed that in the process of work in conditions of the general uniform illumination with LED cold-white lighting of Tcolor = 5999 K, following hygienic requirements, work capacity rates in workers were higher and more stable than with LED Tcolor = 2700 K.

Purpose of the work. Studying and comparative analysis of the effect of LED radiation with Tcolor = 6000 K on the content of melatonin in the body of office workers, working in conditions of LED and luminescent lighting.

Methods. The content of 6-sulfatoximelatonin metabolite in urine of 10 office economists, performing their occupational tasks in conditions of the light environment, equipped with LED with Tcolor = 6000 K under the illumination of 350–400 Lux from the system of the general uniform illumination within 2 months, was studied. The control group covered 10 economists of the other office aged 25–30, working in equal conditions as the main group, but under illumination with linear luminescent lamps of the same Tcolor K.

Conclusion. It is established that the content of metabolite melatonin in the main group (under less excess) does not practically differ from the content of metabolites in the urine of office workers of the control group, supposing the lack of availability of negative effects from exposure to LED cold-white sources of radiation on the human body ( p < 0,05).

Key words: LED, color temperature, office workers, 6-sulfatoximelatonin metabolite, metabolite metabolism


  1. Berson, D. M., Dunn, A., Takao, M. 2002, ”Phototransduction by retinal ganglion cells, that set the circadian clock”, Science, v. 295, no. 5557, pp. 1070–1073.
  2. Fryc, J., Davis, J., Ohno, O. 2010, Experiment on Visual Perception of Pulsed LED Lighting. Can J. Save Energy for Lighting. Proceedings of CIE 2010 "Lighting Quality and Energy Efficiency". Vienna, Austria, 14– 17 March 2010, pp. 287–289.
  3. Brainard. G. C., Gliekman, G. 2003, The biological potency of light in humans: significance to health and behaviour. CIE, 152, pp. i-22–i-33.
  4. Thapan, K., Arendt, J., Skene, D. J. 2001, “An action spectrum for melatonin suppression: evidence for a novel non-rod, non-con photoreceptor system in humans”, J. Physiol., v. 535, pp. 261–267.
  5. Brainard, G. C. 2002, Photoreception for regulation of melatonin and the circadian system in humans, Fifth Int. LRO Lighting research symp., Orlando.
  6. Ronki, L. R. 2005, “Visual and biological effect of light in the new millennium: proposal for education”, Svetotekhnika, no. 5, pp. 4–9 (in Russian).
  7. Bilund, L. 2011, About the article by E. V. Dolin e. a. “Comparative hygienic assessment of conditions of lighting with luminescent lamps and LED sources”, Svetotekhnika, no. 1, pp. 48–53 (in Russian).
  8. Adrian, V. 2008, “Commentary to the spectrum of radiation effect in regulation of melatonin secretion”, Waterloo University Ватерлоо, School of optometry, Canada”, Svetotekhnika, no.1, pp. 39–41 (in Russian).
  9. Blask, D. E. Brainard, G. C., Dauchy, R. T. [et al.]. 2004, Melatonin suppression by ocular light exposure during darkness: Impact on cancer growth and implication for cancer risk in humans. CIE Symp. on Light and Health: non-visual effects. CIE 027, pp. 42–45.
  10. Stevens, R. G. 2005, “Circadian Disruption and Breast Cancer: from Melatonin to Clock Genes”, Epidemiology, v. 16, pp. 254–258.
  11. Коmarov, F. I., Rapoport, S. I., Malinovskaya, N. К., Anisimova, V. N. 2004, Melatonin in the norm and in pathology. Мoscow : Medpraktika, 308 p. (in Russian).
  12. Van Gelder, R. N. Mawad, К. 2007, “Illuminating the mysteries of melanopsin and circadian photoreception”, J. Biological rhythms, v. 5, pp. 394–395.
  13. Dehoff, P. 2006, Effect of the changing light on human health in work”, Svetotekhnika, no. 3, pp. 54–57 (in Russian).
  14. Brainard, G. К., Prevensio, A. V. 2008, “Perception of light as a stimulus of nonvisual human reactions”, Svetotekhnika, no. 1, pp. 6–12 (in Russian).
  15. Van Bomel, V. 2011, “Lamps for direct change of incandescent lamps and human health”, Svetotekhnika, no. 2, pp. 20–24 (in Russian).
  16. Bizyak, G., Kobaм, M. V. 2012, “Spectra of radiation from LED and the spectrum of action for suppression of melatonin secretion”, Svetotekhnika, no. 3, pp. 11–17 (in Russian).