You are using an outdated browser. For a faster, safer browsing experience, upgrade for free today.

PECULIARITIES OF USING NON-INVASIVE BIOLOGICAL SUBSTRATES IN EXPOSURE BIOMONITORING OF HEAVY METALS IN PRODUCTION

PECULIARITIES OF USING NON-INVASIVE BIOLOGICAL SUBSTRATES IN EXPOSURE BIOMONITORING OF HEAVY METALS IN PRODUCTION

4(33) 2012

DOI xxxxxxxx

Demchenko V. F., Andrusyshyna I. M., Golub I. O., Lampeka O. G., Lubyanova I. P., Yermakova O. V.

PECULIARITIES OF USING NON-INVASIVE BIOLOGICAL SUBSTRATES IN EXPOSURE BIOMONITORING OF HEAVY METALS IN PRODUCTION

SI «Institute for Occupational Health of NAMS of Ukraine», Kiev

Full article (PDF), UKR

The article presents studies of the microelement status of welders. The imbalance of macro- and microelements in non-invasive biological substrates of welders in comparison with the control group has been defined. It was found a positive cor-relation between the content of Cd, Fe, Cr, Mn in non-invasive and invasive biosubstrates. The analysis of relationships between essential elements in some cases showed their non-conformity with physiological norms.

Key words: non-invasive biological substrates, imbalance of macro-and microelements, welders

References

  1. Kundiev Yu.I., Trakhtenberg I.M. (1991),”Ecologo-hygienic aspects of the heavy metal problems as technogenic pollutants””, Gigiyena truda, Issue 27, 3.-8.
  2. Revich B.A. Biomonitoring toksicheskikh veshchestv v organizme cheloveka / B. A. Revich // Gig. i san.- 2004.- No 6.- S. 26-31.
  3. Hapon V. O. Marhanets u navkolyshnomu seredovyshchi ta yoho vplyv na orhanizm / V. O. Hapon, A. B. Yashchenko // Dovkillya ta zdorov'ya.- 2005.- No 2.- S. 69-72.
  4. Belyayev Ye. N. Sovremennaya kontseptsiya gigiyenicheskoy diagnostiki / Ye. N. Belyayev, V. A. Konyukhov, T M. Makarova, N. N. Vereshchagin.- Orenburg: IPK GOU OGU, 2007.- 354 s.
  5. Agadzhanyan N. A. Integrativnaya meditsina i ekologiya cheloveka / N. A. Agadzhanyan, I. N. Polunin.- Moskva-Astrakhan' : KMK, 1998.- 354 s.
  6. Shafran L. N. Soderzhaniye tyazhelykh metallov v biosubstratakh bol'nykh razlichnogo profilya kak marker toksichnykh nefropatiy / Shafran L. N., Bol'shoy D. V., Pykhteyeva Ye. G. // Aktual'nyye problemy transportnoy meditsiny, 2009.- No 1.- S. 29-36.
  7. Skal'nyy A. V. Khimicheskiye elementy v fiziologii i ekologii / Skal'nyy A. V.- M. : ONIKS 21 vek. Mir, 2004.- 215 s.
  8. Kudrin A. V. Mikroelementy v nevrologii / Kudrin A. V., Gromova O. A.- M.: GEOTAR-Media, 2006.- 204 s.
  9. Otsenka elementnogo statusa rabotnikov metallurgicheskogo proizvodstva: metodologicheskiy aspekt / I. N. Fomin, S. P. Sokolov, A. R. Grabeklis [i dr.] // Vestnik OGU,- 2006.- No 12.- S. 278-283.
  10. Konovalova S. O. Sravneniye informativnosti izucheniya razlichnykh biosubstratov dlya monitoringa mineral'nogo obmena / S. O. Konovalova // Ukr. bio- khim. zhurn.- 2002.- T. 4, No 4a.- S.145-146.
  11. Demchenko V.F., Andrusyshyna I.M., Lampeka O.N., Holub I.O. (2010),.Metodychni rekomendatsiyi. Atomno-absorbtsiyni metody vyznachennya makro- ta mikroelementiv u biolohichnykh seredovyshchakh pry porushenni yikh obminu v orhanizmi lyudyny [Methodical recommendations. Atomic-absorption methods for determining macro- and microelements in biological media in disorders of their metabolism in the human body], Avicenna, Kyiv, Ukraine.
  12. Metodicheskiye ukazaniya 4.1.1482-03 “Opredeleniye khimicheskikh elementov v biologicheskikh sredakh i preparatakh metodami atomno-emissionnoy spektrometrii s induktivno-svyazannoy plazmoy i mass-spektrometrii s induktivno-svyazannoy plazmoy”.- M. : Minzdrav Rossii, 2003.- 16 s.
  13. Antomonov M. Yu. Matematicheskaya obrabotka i analiz mediko-biologicheskikh dannykh / M. Yu. Antomonov.- K. : FMD, 2006.- 558 s.
  14. Diapazon soderzhaniya tyazhelykh metallov (TM) v tsel'noy krovi vzroslykh rossiyan tsentra strany /G K. Barashkov, I. M. Balkarov, L. I. Zaytseva [i dr.] // Mikroelementy v meditsine.- 2003.- No 4 (3).- S.1-5.
  15. Sheshunov I. V. Otsenka toksichnosti oksidov tyazhelykh metallov pri khronicheskom vozdeystvii na rabochikh s ispol'zovaniyem v kachestve test-ob"yekta ikh slyuny / I. V. Sheshunov, S. V. Smirnov // Toksikologicheskiy vestnik, 2003.- No 4.- S. 31-35.
  16. Revich B. A. Khimicheskiye elementy v volosakh cheloveka kak indikator vozdeystviya proizvodstvennoy i okruzhayushchey sredy / B. A. Revich // Gig. i san.- 1990.- No 3.- S. 55-59.
  17. Shafran L. M. Toksikologiya metallov v reshenii zadach okhrany zdorov'ya naseleniya i okruzhayushchey sredy / L. M. Shafran, D. V. Bol'shoy, Ye. G. Pykhteyeva // Prichernomorskiy ekolog, byul.- 2003.- No 1 (7).- S. 93-100.
  18. Moiseyenko N. N. Soderzhaniye tyazhelykh metallov v biosredakh rabochikh shakhty «Novaya» g. Zheltyye Vody v zavisimosti ot vozrasta i stazha raboty / N. N. Moiseyenko, V. P. Stus', S. V. Berestenko // Tez. mezhd. nauchno-prakt. konf. urolog, i nefrologov.- 1997.- S. 188-195.
  19. Znacheniye spektral'nogo analiza volos v diagnostike narusheniy elementnogo gomeostaza i v otsenke effektivnosti profilakticheskikh i lechebno-reabilitatsionnykh meropriyatiy / N. V. Nagornaya, A. V. Dubovaya, I. P. Goncharenko, I. A. Morozova // Suchasní medichní tekhnologíí̈.- 2009.- No 3.- S. 50-54.
  20. Lubyanova I. P. Osobennosti proyavleniya peregruzki organizma zhelezom u svarshchikov staley i chuguna // ZH. gigiyena truda i professional'nyye zabolevaniya.- 1990.- No 5.- S.10-13.
  21. Soderzhaniye margantsa v volosakh kak test ekspozitsii u svarshchikov / L. N. Gorban', Ye. P. Krasnyuk, I. P. Lubyanova [i dr.] // Vrachebnoye delo.- 1992.- No 5.- S. 85-88.
  22. Comprehensive determination of trace elements in human saliva by ETA-AAS / G. P. Signoli, C. Gordoni, O. Bonori [et al.] // Microchim. Acta.- 1989.- No 1.-P. 171-179.
  23. Elemental anomalies in hair as indicators of endocrinologic pathologies and deficiencies in calcium and bone metabolism / N. Mickeley, L. M. De Carvalho Fortes, C. I. Porto da Silveira, M. B. Lima // J. of Trace Elements in Med. and Biol.- 2001.- V. 15.- Iss. 1.- P. 46-55.
  24. Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, hair and saliva in an occupationally exposed population / F. Gil, A. F. Hernandes, C. Marquez [et al.] // Science of the Total Environment.- 2011.- V. 409.- P. 1172- 1180.
  25. Diagnosis of lung cancer based on metal contents in serum and hair using multivariate statistical methods / Y. Ren, Z. Zhang [et al.] // Talanta.- 1997.- V. 44.- Iss. 10.- P. 1823-1831.
  26. Simultaneous determination of Cd, Cu, Mn, Ni, Pb and Zn in nail samples by inductively coupled plasma mass spectrometry (ICP-MS) after tetramethylammonium hydroxide solubilization at room temperature: Comparison with ETAAS / B. L. Batista, J. L. Rodrigues, J. A. Nunes [et al.] // Talanta.- 2008.- V. 76.- P. 575-579.
  27. Rashed M. N. Heavy metals in fingernails and scalp hair of children, adults and workers from environmentally exposed areas at Aswan, Egypt / M. N. Rashed, F. Hossam // Environmental Bioindicators.- 2007.- V. 2, (3).- P. 131-145.
  28. Validation of a method to quantify chromium, cadmium, manganese, nickel and lead in human whole blood, urine, saliva and hair samples by electrothermal atomic absorption spectrometry / P Olmedo, A. F. Hernandez, J. Lopez-Guarnido, R. F. Gil // Analytica Chimica Acta.- 2010.- V. 659, No 1-2.- P 60-67.
  29. Neurological and respiratory symptoms in shipyard welders exposed to manganese / T Halatek, H. Sinczuk-Walczak, M. Szymczak, K. Rydzynski // Int. J. Occup. Med. Environ. Health.- 2005.- V. 18, No 3.- P 265-274.
  30. Wang D. Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders / D. Wang, X. Du, W. Zheng // Toxicol Lett.- 2008.- P 290-295.