Yastrub T. O., Kirsenko V. V.
SI «Institute for Occupational Health of NAMS of Ukraine», KyivFull article (PDF), UKR
Introduction. Production and use of biological products is becoming increasingly important additives to chemical agents, and in the case of organic farming - an environmentally pure alternative. Effective means of biological control of insect pests are based on baculovirus biologics, which are part of the natural microbiota and play an important role in maintaining the balance of insects in natural biocenosis.
Purpose of the study. Toxicological-hygienic evaluation of biopesticide Helikoveks, KS (acting ingredient — Helicoverpa armi- gera nucleopolyhedrovirus (HearNPV) isolate BV-0003, titer — 7,5 • 1012 polyedras/l) produced by Andermatt Biocontrol AG (Switzerland) from the point of view of safety to human health and the environment
Materials and methods. Methods: analytical, toxicological, hygienic. Experimental toxicological studies performed in accordance with the requirements of OECD 401, 402, 404, 405, 406 (OECD Guideline for the Testing of Chemicals: «Acute Oral Toxicity», «Acute Dermal Toxicity», «Acute Dermal Irritation/Corrosion», «Acute Eye Irritation/Corrosion», «Skin Sensitization» compliance with key provisions of bioethical treatment of animals. The grounding of sanitary require¬ments of the preparation was made using official documents regulating the safety of pesticides during their post-registration application.
Results. It is established that biological product Helikoveks COP according to the «Hygienic classification of pesticides by the degree of hazard safety» (DSanPiN 184.108.40.206.002-98) parameters for acute oral, inhalation, dermal toxicity refers to Class 4 of hazard (low hazard) ( sanitary standards), it shows no irritating effect on skin and mucous membranes of eyes and have no sensitizing properties. The control of production and the environment, as well as agricultural products grown using this preparation, due to its toxicological safety, is not needed. Waiting periods to harvesting crops, cultivated with the use of this preparation are not regulated; re-entry periods for mechanized / manual works are 1 day. The conditions of safe use of this biological product are defined according to application instructions and requirements of DSanPiN 220.127.116.11.001-98 «Transport, storage and use of pesticides in the national economy».
Conclusions. According to the results of toxicological and hygienic assessment of this biopreparation of insecticidal activity «Helikoveks, KS», there have been developed instructions for its safe use in the studied field and recommendations are pro-posed for state registration in Ukraine.
Key words: baculovirus, biological insecticide Helikoveks, SC, safety assessment