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STATE OF IMMUNITY AND AUTOIMMUNITY IN COAL MINERS WITH PNEUMOCONIOSIS

3(23) 2010

DOI xxxxxxxx

Nikolenko V. Y.1, Solodilov A. I.2, Lastkov D. O.1, Nikolenko O. Y.1

STATE OF IMMUNITY AND AUTOIMMUNITY IN COAL MINERS WITH PNEUMOCONIOSIS

1National Medical University named after M. Gorky, Donetsk
2District clinical hospital for occupational patients, Donetsk


Full article (PDF), UKR

An immunologic survey of 137 miners with pneumoconiosis and 47 healthy miners has shown that there is a decrease in the quantity of ^ and B-lymphocytes and their subpopulations. The number of phagocytized neutrophils and staphilococcuses, seized by them, decreased significantly in miners with pneumoconiosis. The increase of the level of interleukin 6 and the content of all immunoglobulins and, also, circulating immune complexes, was found in patients. The increase of the level of autoantibodies up to six explored autoantigens was noted in lungs, thymus, spleen, kidneys, joints, nDNA and dDNA, pon- ting to the development of system autoimmune responses in pneumoconiosis.

Key words: pneumoconiosis, immunity, coalminers

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