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Rudenka K. L.


State Institution "O. S. Kolomiychenko Institute of Otolaryngology of National Academy of Medical Sciences of Ukraine", Kiev

Full article (PDF), UKR

Introduction. The impact of noise and vibration on the human body is one of the major hazards/noxious agents of the environmental and industrial production, causing a sensorineural hearing loss (SNHL). According to the WHO data of 2002, noise is the second largest occupational risk factor by health and social damage.

Objective. To determine the effectiveness of trofin action in experimental sensorineural hearing loss, induced by aminoglycoside antibiotics.

Materials and methods. Experimental studies were performed on 37 mature guinea pigs. A modeling of SNHL was made using gentamicin, which was administered daily for 14 days in the dose of 50 mg/kg (group 2). At the background of gentamicin administration, animals of 3–6 groups received trofin at the dose of 0,4 ml/kg intramuscularly and intraperitoneally.

Results. Significant disorders in the microcirculatory elements of the bone and the membranous labyrinth have been observed on the background of a 14-fold administration of gentamicin. Thus, the blood vessels demonstrated congestion; their lumens were blood-clotted. The spiral ligament was very swollen and of uneven thickness; sludge was observed in capillaries. Hair cells and cochlear were so swollen, that their line was broken. The injection of trofin completely neutralized a negative effect of aminoglycoside antibiotic, irrespective of the method of administration.

Conclusions. The results of experimental studies give occasion to the hope for the possibility of effective use of trofin for treatment of patients with sensorineural hearing loss.

Key words: hearing loss, aminoglycoside antibiotic, trofin, guinea pigs, inner ear


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