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Three-r principle and ways of its implementation in hygienic and toxicological practice

3-4 '2005

https://doi.org/10.33573/ujoh2005.03.066

Korshun M.M.1 Krasnokutska L.M.2

Three-r principle and ways of its implementation in hygienic and toxicological practice

1 Hygienic regulation Committee Ministry of Public Health of Ukraine, Kiev

2 Institute for Occupational Health of AMS of Ukraine, Kiev

Full article (PDF), RUS

The article deals with the three-R principle - reducing the number of animals in the experiment, replacing vertebrate ani-mals by cell cultures, mathematic modeling or using animals of lower organizational structure, careful treatment of animals in the toxicological experiments aiming at hygienic regulation of the hazardous substances.Authors consider propaganda and practical implementation of three-R principle to be an efficient factor for implementing bioethics requirements into everyday activity of scientific institutions and bioethics committees of hygienic profile.

Key words: bioethics, toxicological and hygiotic studies, alternative modelling, three-R principle

References

  1. Berezovskaya I.V. Eticheskiye problemy eksperimental'noy lekarstvennoy toksikologii//Toksikol. vesti.- 1999,- No 6.- S. 2-8.
  2. Gibulgalimova R.A, Sokolov V.V. Ispol'zovaniye eritrotsita dlya otsenki vozdeystviya khimicheskikh soyedineniy na organizm rabotayushchikh//Gig. truda i prof. zabol.- 1988.- No 7,- S. 28-30.
  3. Yesin M.S., Eskin A.M., Vigdergauz M.S. Primeneniye khromatograficheskoy modeli dlya prognozirovaniya toksichnosti i opasnosti neelektrolitov//Gig. truda i prof. zabol.- 1988.- No10.- S. 25-27.
  4. Krasovskiy G.N., Yegorova N.A. Kriterii opasnosti galogensoderzhashchikh veshchestv, obrazuyushchikhsya pri khlorirovanii vody//Toksikol. vestn.- 2002.- No 3.-S. 12-17.
  5. Yes'kov M.S., Kayumov R.I., Sokolov A.Ye. Toksikologicheskiye ispytaniya. Al'ternativnyye metody//Toksikol. vesti.- 2003.- No 5.- S. 25-29
  6. Krasovskiy G.N., Yegorova N.A., Antonova M.G. Problemy ekstrapolyatsii rezul'tatov biotestirovaniya na cheloveka//Toksikol. vestn.- 2000.- No 6.- S. 13-19.
  7. Krasovskiy G.N., Sobinyakova O.R. Sravnitel'naya chuvstvitel'nost' cheloveka i zhivotnykh k deystviyu razlichnykh veshchestv po pokazatelyam ostroy toksichnosti//Gig. i san.- 1970.-No 4.-S. 29-34.
  8. Kul'tura zhivotnykh kletok. Metody. Per. s angl./Pod red. R.Freshni,- M., 1989.- 333 s.
  9. Kurlyandskiy B.A. O nekotorykh aktual'nykh problemakh, svyazannykh s gigiyenicheskim normirovaniyem//Gig. i san.- 1985.- No 10,- S. 50-52.
  10. Kurlyandskiy B.A., Rotenberg YU.S., Zav'yalova N.V. K obosnovaniyu kriteriya otbora pri toksikologicheskoy otsenke novykh toksicheskikh zhidkostey/ /Gig. i san.- 1974.- No 4.- S. 86-89.
  11. Kundiev Yu.I. Korshun M.N. (2000), “Hygienic regulation as a problem of bioethics”, Mezhdunar. Med. zhurnal,.6 (4), 6-11.
  12. Lazarev N.V. Problemy izucheniya toksicheskikh svoystv vnov' poyavlyayushchikhsya v promyshlennosti veshchestv//Gig. truda i prof. zabol- 1962 –No 11 .S. 6-11.
  13. Loyt A.O., Radilov A.S., Men'shikov N.M. Toksikologicheskaya ekspertiza novykh khimicheskikh veshchestv// Med. truda i prom. ekol.- 1993.- No 7-8.- S. 37-40.
  14. Metodicheskiye rekomendatsii po ispol'zovaniyu kul'tury diploidnykh embrional'nykh kletok cheloveka, rekomenduyemykh dlya toksikologicheskikh issledovaniy.-M.: M3 SSSR. 1991.
  15. Otsenka toksichnosti spirtov i vodok. Ekspress-metod s ispol'zovaniyem v kachestve test-ob"yektov spermy krupnogo rogatogo skota. Metodicheskiye rekomendatsii.- M.: M3 RF. 2001.
  16. Partsef D.P. Khronicheskoye deystviye na org¬nizm zhivotnykh nekotorykh komponentov vykhlopnykh gazov avtomobiley//Gig. i san.- 1966.-No 9.-S. 11-15.
  17. Rotenberg YU.S. Eksperimenty na izolirovannykh mitokhondriyakh i vozmozhnost' kolichestvennogo perenosa poluchennykh rezul'tatov na tselostnyy organizm//Rukovodstvo po izucheniyu biologicheskogo okisleniya polyarograficheskim metodom.- M.: Nauka. 1973.-S. 213-217.
  18. Serdyuk A.M., Tymchenko 0.1., Tymchenko A.S., Hylahan V.O. Bioetychni aspekty diyalʹnosti naukovoho spivtovarystva//Dovkillya ta zdorov'ya.- 2002.- No 1 (20).-S. 3-5.
  19. Sidorin G.I., Lukovnikova L.V., Frolova L.D. O vozmozhnosgyakh i ogranicheniyakh «al'ternativnykh» metodov issledovaniya v toksikologii//Mater. mezhdunar. simpoz. «Zdorov'ye i khimicheskaya bezopasnost' na poroge XXI veka».- Spb. 2000,- 24 s.
  20. Ukrayinsko-amerykanskyy seminar z pytan bioetyky. 10-12 hrudnya 2001 r,- K., 2001.
  21. FilenkoO.F., Isakova I.F. Kompensatornyye izmeneniya v otvete dafniy na letal'nyye vozdeystviya. Reaktsiya gidrobiontov na zagryazneniye.- M.: Nauka. 1983.-S. 135-139.
  22. Fedoseyeva T.A., Men'shikova T.A. Otsenka toksichnosti sinteticheskikh chistyashchikh i moyushchikh sredstv metodom in vitro na kratkovremennoy suspenzionnoy kul'ture kletok - spermy byka//Toksikol. vestn.-2004,-No 6.-S. 17-20.
  23. Sheftel' V.O. O srokakh vozdeystviya pri modelirovanii intoksikatsii v toksikologo-gigiyenicheskikh issledovannyakh//Gig. i san.- 1986,- No 8.- S.70-73.
  24. Sheftel' V.O., Kagan YU.S. Printsip etapnosti v provedenii eksperimental'nykh toksikologo-gicheskikh issledovaniy po gigiyenicheskomu normirovaniyu khimicheskikh zagryazniteley okruzhayushchey sredy//Gig. i san.- 1987.-No 11.-S. 46-50.