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TO THE PROBLEM OF CADMIUM NEPHROTOXICITY

2(22) 2010

DOI xxxxxxxx

Dmytrukha N. M.

TO THE PROBLEM OF CADMIUM NEPHROTOXICITY

SI «Institute for Occupational Health of AMS of Ukraine», Kyiv

Full article (PDF), UKR

Changes of immunological reactivity of Wistar rats after cadmium exposure and a role of immune complexes are examined in the article, from the point of view of cadmium nephrotoxicity development. As a result of a sub-chronic experiment cadmium cumulation in liver and kidneys, changes in neutrophilic phagocytic activity, decrease of the complement titer, increased level of pathogenic low-molecular CIC have been found. The increase of the CIC level in blood serum and disorders in their elimination promoted deposition of immune complexes in capillaries and mesangium of kidney glomerules in rats, which is likely to be a sign of immune complex glomerulonephritis development in chronic cadmium intoxication.

Key words: cadmium sulfate, immunotoxicity, cadmium intoxication, nephrotoxicity

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