Andrusyshyna I., Golub I., Lampeka E.
TO THE PROBLEM OF SUBSTANTIATION OF OPTIMUM LEVELS OF HEAVY METALS IN HUMAN BIOLOGICAL MATERIALS
SI "Institute for Occupational Health NAMN", Kyiv
Introduction. A multielement analyis of biological fluids is one of factors of mass screening and control of environmental factors’ effect on the human body and animals. At present, specialists of all over the world understand that reference meanings as well as the concept "norm" are not a constant value due to heterogeneity of geochemical conditions of habitation. The use of different analytical methods in definition of chemical elements resulted in significant controversies in interpretation of a physiological “norm” in human biological media.
Purpose of the study. To give an ecological-hygienic assessment of heavy metals’ effect on formation of optimal levels in their content in biological media.
Materials and methods. The content of heavy metals was defined in subjects of the environment (atmospheric air, drinking water, food products) and in biological media of individuals-volunteers (hair, general blood, blood serum). In order to define heavy metals in samples an atomic emission spectrometry with inductively connected plasma was used and a method of mathematic statistics.
Results. The obtained results do not leave any doubts on the availability of a tight connection between chemical composition of the air, drinking water, food products in formation of optimum levels in the content of macro- and microelements in human biological media. In order to reveal a risk of imbalance development in macro- and microelements in the human body it is necessary to conduct a multielement analysis both at individual and population level.
Key words: heavy metals, reference meanings, macro- and microelements, biological media
- Skalny, A. V., Lakarova, E. V., Kuznetsov, V. V., Skalnaya, M. G. 2009, Analytical methods in bioelementology. Nauka, St. Petersburg, 264 p. (in Russian).
- Trakhtenberg, I. M. 2001, Basic indices of a physiological norm in man, Guide for toxicologists, Kiev : Avicenna, 372 p. (in Russian).
- Notova, S. V., Miroshnikova, S. A., Bolodurna, I. L., Didikina, E. V. 2006, “The need to record regional peculiarities in modeling processes of interelement interrelations in the human body”, Vestnik of OGU, no. 2, pp. 59–63 (in Russian).
- Tolmachevа, N. V., Suslikov, V. L., Vinokur, T. Yu. 2011, “Ecological and physiological substantiation of standards for optimum levels and a ratio of macro- and microelements in drinking water and daily food diet”, Medical Sciences, no. 3, pp. 155–160 (in Russian).
- Shafran L. M., Bolshoy, D. V., Pykhteyeva, E. G. 2009, “The content of heavy metals in biosubstrates of patients of various occupations as a marker of toxic nephropathies”, Actual problems of transport medicine, no. 1, pp. 29–36 (in Russian).
- Andrusishina, I. M., Lampeka, O. G., Golub, I. O. [et al.]. 2014, Methodical recommendations 72.14 / 133.14, 2014, "Assessment of mineral metabolism disorders in occupational contingents using a method of atomic absorption spectrometry with inductively connected plasma". Kyiv : Avicenna, 56 p. (in Ukrainian).
- Determination of 33 elements by atomic emission spectrometry with inductively connected plasma in water. 2007, State standard ISO 11885: 1996. Kyiv : Derzhspozhyvstandart Ukrainy,14 p. (in Ukrainian).
- Metal and metalloid particulates in workplace atmospheres (ICP analysis) File://E:/nioshdbs/ oshameth/id125g/id25/id15g.htm
- Interstate standard. GOST 30538-97. 2000, Food products. Procedure of determination of toxic elements by atomic-emission method, 32 p. (Adopted by the State Standard of Ukraine № 12 of 11.21.97).
- Antomonov, M. Y. 2006, Mathematical processing and analysis of medical and biological data. Kiev : MDK, 558 p. (in Russian).
- Methodical recommendations on determination of a real load of chemicals, coming from the atmospheric air, water and food products, 1986, Moscow, 40 p. (in Russian).
- Resolution of the Cabinet of Ministers of Ukraine "On approval of sets of food products, nonfoods and services for main social and demographic population groups " of 14.04.2000 № 656, 28 p. (in Ukrainian).
- Paranko, N. M., Belitskaya, E. N., Karnaukh, N. G. [et al.]. 2002, Heavy metals of the environment and their effect on the immune status of the population, Dnepropetrovsk : Poligrafist, 146 p. (in Russian).
- Gil, F., Hernande, A. F., Marquez, C. [et al.]. 2011, “Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, hair and saliva in an occupationally exposed population, Science of the Total Environment, v. 409, pp. 1172–1180. https://doi.org/10.1016/j.scitotenv.2010.11.033
- Daskakova, A., Gabrashanska, M. 2005, Comparative investigation on microelement levels in samples from soil, water, fodder and internal organs of wild animals”, Fifth Inter. Symp. ”Metals ions in biology and medicine”, Greece, v. 5, pp. 776–780.