Yastrub T. A.


State Institution "Institute for Occupational Health of the National Academy of Medical Sciences of Ukraine", Kyiv

Full article (PDF), UKR

Introduction. Gibberellins – natural plant hormones which exhibit properties of growth regulators and inducers of natural protective mechanisms of plant cells and are used in technologies of crop growing.

Purpose of the study. Toxicological-hygienic evaluation of preparations, based on gibberellins – plant growth regulators "Zav’yaz" (gibberellins sodium salt A3, A4, A7 – 5,5 g/kg) and "Novahib" (gibberellins GA4 / 7–10 g/l) from the standpoint of safety for human health and the environment

Materials and methods. Expert-analytical studies of technical documents on the formulated products, literature data on toxicological properties of gibberellins, their behavior in the environment, risk assessment models for prediction and quantitative assessment of inhalation and dermal exposure to gibberellins.

Results. In accordance with the "Hygienic classification of pesticides by the degree of hazard" (SSanR&N, gibberellins GA3 and GA4/7 are referred to Class 4 by hazard according to parameters of acute oral and dermal toxicity and by acute inhalation toxicity – to Class 2–3, they do not irritate the skin, are moderate irritants of the mucous membranes of eyes and have no allergenic potential. It is established, that under short-term and lon term toxicological exposures gibberellins show a general toxic effect on the body with predominant influence on the renal function. Gibberellin are unstable in the soil and moderately persistent in the water, quickly decomposed in the air and are safe for bees and useful entomofauna, soil organisms, birds. They are not toxic for aquatic organisms, do not accumulate in plants and the environment. By results of toxicological and hygienic assessment of the formulated products "Zav’yaz" and "Novahib" and risk assessment a conclusion has been made about a sufficient degree of safety for human health and the environment ,subject to keeping to guidelines on the application.

Conclusions. In view of the high selectivity for plants, low toxicity and due to natural origin and low application rates of gibberellin (maximum 5 g a.i. / ha) it is not reasonable to control subjects of the environment in case of using plant growth regulators on their base.

Key words: gibberellins, plant growth regulators, toxicity, hygienic assessment, risk prediction


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