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Use of biomonitoring methodology for evaluation of exposure of the population and workers to metals

ISSN 2223-6775 Ukrainian journal of occupational health Vol.16, No 3, 2020

Use of biomonitoring methodology for evaluation of exposure of the population and workers to metals

Andrusyshyna I. M.1, Golub I. O.1, Vorobyov E. I.2, Demchenko V. F.1, Lampeka O. G.1

1SI "Kundiiev Institute of Occupational Health of the NAMS of Ukraine”, Kyiv, Ukraine

2Research Center of the Technological University, Compiegne, France


Full article (PDF), UKR

Introduction. The article reflects current ideas on the methodology of assessment of exposure to heavy metals and other chemical elements, highlights the benefits of human biomonitoring, which includes the choice of biomarkers and informative biological substrates, data collection on sources of the environmental pollution and use of national regulations and standards.

The aim of the study. To evaluate the normative and methodological bases on human biomonitoring, approaches to the evaluation of procedures and results of research on metals in standardized samples and in biological media of persons with different functional status (age, healthy individuals and occupational groups).

Materials and methods. The biological media was used in the study - whole blood and hair and the tested biomaterial (whole blood). Among the surveyed persons, 2 groups were formed: the first - volunteers who had no signs of health disorders (58 people) and the second - which consisted of people who were in occupational contact with metals at workplace (electric welders, jewelers and battery attendants - 57 people). In the biological media of the subjects (whole blood, serum and hair) the content of 7 chemical elements (Al, Ag, Mn, Cd, Cr, Pb and Se) was determined, using a method of multi-element analysis - optical emission spectrometry with inductively coupled plasma (ОЕS-ICP).

Conclusions. Для кількісної оцінки рівня вмісту важких металів і мікроелементів в організмі, що  здатні спричинити розвиток патологічних процесів, рекомендується використовувати комплекс біологічних середовищ людини To quantify the level of heavy metals and trace elements in the body that can cause the development of pathological processes, it is recommended to use a set of biological human media (urine, blood, hair, and others), which are of different diagnostic significance. The study of quantitative assessment of the levels of heavy metals and trace elements in human biological media it is recommended to use the developed, unified, certified and approved in Ukraine chemical-analytical methods of the control.
           Key words: heavy metals, essential microelements, biological media, admissible levels, biomonitoring, elemental homeostasis.



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