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VAZOTOXIC EFFECT OF LEAD: ROLE OF DISORDERS IN NITRIC OXIDE METABOLISM

VAZOTOXIC EFFECT OF LEAD: ROLE OF DISORDERS IN NITRIC OXIDE METABOLISM

https://doi.org/10.33573/ujoh2007.03.056

Apykhtina O.L.1, Kotsuruba А.В.2, Korkach Yu.P.2, Andrusishyna I.М.1, Lampeka O.G.1

VAZOTOXIC EFFECT OF LEAD: ROLE OF DISORDERS IN NITRIC OXIDE METABOLISM

1Institute for Occupational Health of AMS of Ukraine, Kyiv

2Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv

Full article (PDF), UKR

The role of disorders in production and metabolism of nitrogen oxide in tissues of aorta under lead exposures is considered. The ability of lead to cumulate in the aorta, to significantly stimulate production of reactive oxygen species and cause inten¬sive changes in the nitric oxide system, resulting in the increase of activity of inducible isoform of nitric oxide synthase and in the level of its main metabolites, is determined. Here, preconditions for substantial development of a highly toxic sub¬stance — peroxinitrite are created, resulting in the strengthening of its cytotoxic effect and occurrence of the relative nitro¬gen oxide deficiency.

Key words: nitric oxide, lead, aorta, peroxinitrite, vazotoxic action

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