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Analytical issues of cosmetic safety assessment methodology (literature review)

Analytical issues of cosmetic safety assessment methodology (literature review)

ISSN 2223-6775 Ukrainian journal of occupational health Vol.17, No 4, 2021


https://doi.org/10.33573/ujoh2021.04.272

Analytical issues of cosmetic safety assessment methodology (literature review)

Yastrub T.O., Prygunova V.V., Khudenko N.V., Dontsova D.O., Hrygorieva K.V., Kovalenko V.F.
State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv


 Full article (PDF): ENG / UKR

Introduction. Since July 2013 in the European Union (EU) came into force a ban on testing cosmetic products on animals, this ban is supported by a number of countries in the world, including Ukraine. Along with this, the problem of introducing alternative methods of testing cosmetic products, determining the toxicological endpoints and testing strategies for new ingredients is relevant. The article provides a practical overview of methods for assessing the safety of cosmetic products, taking into account the current approaches used in the EU.

Purpose of the study. Analytical review of modern methods of assessing the safety of cosmetic products.

Materials and methods. The study is based on an analysis of domestic and foreign publications, current regulations and guidance documents of international organizations governing the circulation of cosmetics.

Results. Assessing the safety of cosmetic products involves various approaches, including animal testing data (in vivo) conducted before 2013, methods using cell lines and tissues (in vitro), and computer simulation methods (in silico). The damaging effects of cosmetic products on the skin are most often evaluated using three-dimensional models of artificial skin, and the damaging effects on the eyes are investigated both by methods of cellular analysis and using the eyes of dead animals. At the same time, the available alternative methods do not meet the need to assess all toxicological parameters (acute toxicity, embryonic toxicity, endocrine toxicity, carcinogenicity, and repeated-dose assessment). Under such conditions, computer modeling methods are of particular relevance.

Conclusions. Assessing the safety of cosmetic products requires careful planning and development of testing strategies that include searching for available information on tests performed on animals, using alternative in vitro models, and involving in silico methods.

Key words: cosmetic products, safety assessment, alternative methods, computer simulation methods.

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