Cardio-vasotoxic effect of heavy metal compounds and their nanoparticles (review)
Trachtenberg I.M., Dmytrukha N.M., Kozlov K.P.
State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv
Full article (PDF): ENG / UKR
Introduction. Pathology of the cardiovascular system is one of the leading causes of morbidity and mortality in Ukraine. Many researchers attribute it to the effects of adverse occupational and environmental factors. Heavy metals and their compounds are among "classic" risk factors for cardiovascular disease. To date, it has been established that heavy metals in the form of ultadisperse particles with a size of <100 nm may be present in the air in some industries. The physicochemical properties of these particles help to overcome biological barriers and enhance the accumulation and toxic effects of heavy metals. Thus, the study of the characteristics and target organs of the toxic effects of heavy metal compounds and their nanoparticles (NPs) as anthropogenic pollutants on health of workers and the general population is an actual problem for occupational health and industrial toxicology.
The aim of the study. Search and data analysis of literature on the exposure to heavy metals, their NPs on the cardiovascular system, determining the features and mechanisms of their cardiovasotoxic action, establishing further prospects for assessing the safety of nanotechnologies and nanomaterials.
Materials and methods. Analytical review of modern scientific publications was performed using information databases Portalnano, PubMed and VI Vernadsky National Library of Ukraine using Internet resources.
Results. The article presents literature data on the features and mechanisms of the impact of heavy metals on the cardiovascular system, as well as the results of the study of cardiovasotoxic effects of metal NPs. Data from experimental, clinical and epidemiological studies prove that heavy metals such as lead, cadmium, iron, play an important and often leading role in the pathogenesis of cardiovascular disease in workers, including the development of hypertension, atherosclerosis and cerebrovascular pathology. At the same time, metal NPs have greater cumulative and toxic activity against heart and vascular cells, which is the cause of their death and dysfunction.
Conclusions. The obtained data allow us to conclude that the cardiotoxic effects of both heavy metals and their NPs are based on two main mechanisms: the impact on the structure and integrity of heart tissue and on the conduction system of vascular endothelium. Metal NPs in comparison to their micro- and ionic forms, easily overcome biobarriers, accumulate in heart tissue, stimulate oxidative stress and apoptosis of cells. The dominant mechanism in the development of cardiovascular diseases is their cyto- and genotoxic effect on cardiomyocytes and endothelial cells.
Keywords: heavy metals, metal nanoparticles, cardiovascular system toxicity.
References
- Kundiev, Yu.Y. and Trakhtenberh, Y.M. (2007), Khimicheskaia bezopasnost v Ukraine: ezhehodnye chteniia, posviashchennye pamiaty Evheniia Yhnatevicha Honcharuka (polnyi tekst doklada), Avitsenna, Kyiv, 71 p.
- Zerbino, D.D., Solomenchuk, T.M. and Skyibchyk, V.A. (2003), "Koronarna khvoroba sertsia ta infarkt miokarda u khvorykh molodoho viku: rol ksenobiotykiv (fakty, hipotezy, komentari)", Ukrainskyi kardiolohichnyi zhurnal, No. 1, pp. 14-21.
- Horbas, I.M. and Smyrnova, I.P. (2009), "Faktory ryzyku ta yikh vzaiemozviazok iz sertsevo-sudynnymy zakhvoriuvanniamy", available at: https://compendium.com.ua/uk/clinical-guidelines-uk/cardiology-uk/section-4-uk/glava-1-faktori-riziku-ta-yih-vzayemo-zv-yazok-iz-sertsevo-sudinnimi-zahvoryuvannyami/
- Trakhtenberh, I.M. and Tychinin, V.A. (2003),"Problema kardiovazotoksicheskoho deistviia ekzohennykh khimicheskikh veshchestv", Ukrainskyi kardiolohichnyi zhurnal, No. 5, pp. 108-114.
- Trakhtenberh, I.M., Apykhtina, O.L. and Lubianova, I.P. (2009), "Rol metaliv yak tekhnohennykh khimichnykh zabrudniuvachiv u patohenezi sertsevo-sudynnykh zakhvoriuvan", Ukrainskyi kardiolohichnyi zhurnal, No. 9, pp. 12-19.
- Demetskaia, A.V., Kucheruk, T.K. and Salnykova, N.A. (2005), "Vozmozhnaia rol nanochastyts tverdoi sostavliaiushchei svarochnykh aerozolei v razvytyy professyonalno obuslovlennoi patolohy". Aktualni problemy hihiieny pratsi, profesiinoi patolohii i medychnoi ekolohii Donbasu,zb. statei, Kashtan, Donetsk, pp. 193-196.
- Sevalniev, A.I., Sharavara, L.P., Kutsak, A.V. et.al. (2020), "Nanochastynky v povitri robochoi zony yak faktor ryzyku zdorovia pratsiuiuchykh u riznykh haluziakh vyrobnytstva", Medychni perspektyvy, Vol. XXV(3), pp. 169-176. https://doi.org/10.26641/2307-0404.2020.3.214859
- Kundiiev, Yu.I., Demetska, O.V., Kucheruk T.K. et.al. (2008), "Biotekhnolohichna aktyvnist chastynok nanodiapazonu v zalezhnosti vid yikh rozmiru", Onkolohiia, No. 10(2), pp. 217-220.
- Trakhtenberg, I.M.and Dmytrukha, N.M. (2013), "Nanoparticles of metals, methods of definition, spheres of use, physico-chemical and toxic properties", Ukrainian journal of occupational health, No. 4 (37), pp. 62-74. https://doi.org/10.33573/ujoh2013.04.062
- Yavorovskyi, O.P., Tkachyshyn, V.S., Arustamian O.M., Kostiuchenko A.M. and Soloha N.V. (2016), "Nanochastynky i nanomaterialy: budova, fizyko-khimichni vlastyvosti, vplyv na orhanizm pratsivnykiv", Dovkillia ta zdorovia, No. 3(79), pp. 29-36. https://doi.org/10.32402/dovkil2016.03.029
- Hasan Badie Bostan, Ramin Rezaee, Mahmoud Gorji Valokala. (2016), "Cardiotoxicity of nano- particles", Life Sciences, No.16, pp. 91-99. https://doi.org/10.1016/j.lfs.2016.09.017
- Mokhtar Ibrahim Yousef, Abdelsalam Abdalla Abuzreda, Maher Abdel-Nabi Kame (2019)," Cardiotoxicity and lung toxicity in maile rats induced by long-term exposure to iron oxide and silver nanoparticles", Experimental and therapeutic medicine, No.18, pp. 4329-4339. https://doi.org/10.3892/etm.2019.8108
- Mo Tao Zhu, Wei Yue Feng, Bing Wang, Tian Cheng Wang, Yi Qun Gu, Meng Wang, Yun Wang, Hong Ouyang, Yu Liang Zhao, Zhi Fang Chai (2008), "Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats", Toxicology, No. 247(2-3), pp. 102-111. https://doi.org/10.1016/j.tox.2008.02.011
- Trakhtenberh I.M. (Ed.) (2010),. Profilaktychna toksykolohiia ta medychna ekolohiia. Vybrani lektsii dlia naukovtsiv, likariv ta studentiv, za zahalnoiu redaktsiieiu akademika NAMN Ukrainy I.M. Trakhtenberha, AVITSENA, Kyiv, 248 p. ISBN 978-966-2144-27-7
- Ethard W. Van Stee (Ed.) (1982), Cardiovascular toxicology, N.-Y. , 388 p.
- Kurliandskogo B.A. and Filova V.A. (Ed.) (2002), Obshhaia toksikologiia. Medicina, Moscow, 608 p.
- Solomenchuk, T.M. (1996), "Arterialna hipertenziia i faktory ryzyku yii vynyknennia sered liudei, yaki zaznaiut vplyvu promyslovykh spoluk svyntsiu", Ukrainskyi kardiolohichnyi zhurnal, No. 2, pp. 56-58.
- Ahmetzyanova, Je.H. and Bakirov, A.B. (2006), "Rol svinca v formirovanii arterialnoj gipertenzii (obzor literatury)", Medicina truda i promyshlennaya ekologiia, No. 5, pp. 17-21.
- Boscolo P. and Carmignani M. (1988), "Neurohumoral blood pressure regulation in lead exposure", Environ Health Perspect., No. 78, 101-106. https://doi.org/10.1289/ehp.8878101
- Trakhtenberh I.M. (Ed.), (2016), Narysy z toksykolohii vazhkykh metaliv. Vypusk I - Svynets, za zahalnoiu redaktsiieiu akademika NAMN Ukrainy I.M. Trakhtenberha, Avitsena, Kyiv, 112 p. ISBN 978-966-2144-83-3
- Apykhtina O. L. (2009), "Vazotoksychna diia svyntsiu: endotelialna dysfunktsiia yak naslidok porushen u systemi endohennoho oksydu azotu" Zhurnal AMN Ukrainy, No. 15(2), pp. 346-354.
- Apykhtina O.L., Kotsuruba A.B., Korkach Yu.P., Andrusishyna I.M. and Lampeka O.G. (2007), "Vazotoxic effect of lead: role of disorders in nitric oxide metabolism", Ukrainian journal of occupational health, No. 3(11), pp. 56-62. https://doi.org/10.33573/ujoh2007.03.056
- Trakhtenberh I.M. (Ed.), (2017), Narysy z toksykolohii vazhkykh metaliv. Vypusk III - Kadmii, za zahalnoiu redaktsiieiu akademika NAMN Ukrainy I.M. Trakhtenberha, Avitsena, Kyiv, 64 p. ISBN 978-966-2144-95-6
- Groneberg, D.A., Godt, J., Scheidig, F. and Grosse-Siestrup, C. (2006), "The toxicity of cadmium and resulting hazards for human health", Journal of Occupational Medicine and Toxicology; No. 1, 22-28. https://doi.org/10.1186/1745-6673-1-22
- Jie Liu, Qu Wei and B. Kadiisha (2009), "Jxidative stress in cadmium toxisity and carcinogenesis", Toxicology and applied pharmacologe, No. 238(3), pp. 209-214. https://doi.org/10.1016/j.taap.2009.01.029
- Trakhtenberh I.M. (Ed.), (2017), Narysy z toksykolohii vazhkykh metaliv. Vypusk V - Zalizo, za zahalnoiu redaktsiieiu akademika NAMN Ukrainy I.M. Trakhtenberha, Avitsena, Kyiv, 88 p., ISBN 978-966-2144-96-3
- Lubyanova, I.P. and Timoshina, D.P. (2011), "Osobennosti formirovaniya i diagnostiki professionalnoj i proizvodstvenno obuslovlennoj patologii u rabochih svarochnyh professij" , Vestnik gigieny i jepidemiologii, No. 15(1), pp. 7-16.
- Lubyanova, I.P. (2013), Izbytochnoe zhelezo i patologiya u rabochih svarochnyh professij, pod obshhej redakciej akademika YU.I. Kundieva, Avicena, Kyiv, 240 p.
- Gujja, P., Rosing, D.R., Tripodi, D.J. and Shizukuda, Y.J. (2010), "Iron overload cardiomyopathy: better understanding of an increasing disorder", J. Am. Coll Cardiol, No. 56(13), pp. 1001-1012. https://doi.org/10.1016/j.jacc.2010.03.083
- Albrtsen Jay (2006), "The toxicity of iron, an essential element", Veterynary Medicine, No. 101(2), pp. 82-90. ISSN: 8750-7943,1939-1919
- Ching-Feng Cheng and Wei-Shiung Lian (2013), "Prooxidant mechanisms in iron overload cardiomyopathy", BioMed Research International.No. 2013: 740573, published online 2013, Nov 19. https://doi.org/10.1155/2013/740573
- Yutaka Kohgo, Katsuya Ikuta , Takaaki Ohtake , Yoshihiro Torimoto, Junji Kato (2008), "Body iron metabolism and pathophysiology of iron overload", Int. J. Hematol., No. 88(1), pp. 7-15. https://doi.org/10.1007/s12185-008-0120-5
- Vinchi, F., Muckenthaler, M. U., Da Silva, M.C., Balla, G., Balla, J. and Jeney V. (2014), "Atherogenesis and iron: From epidemiology to cellular level", Front. Pharmacol., No. 5, pp. 94. https://doi.org/10.3389/fphar.2014.00094
- Basuli, D., Stevens, R.G., Torti, F.M. and Torti, S.V. (2014), "Epidemiological associationsbetween iron and cardiovascular disease and diabetes", Front. Pharmacol., No. 5, pp. 117. https://doi.org/10.3389/fphar.2014.00117
- Habib, A. and Finn, A.V. (2014), "The role of iron metabolism as a mediator of macrophage inflammation and lipid handling in atherosclerosis", Front. Pharmacol., No. 5, pp. 195. https://doi.org/10.3389/fphar.2014.00195
- Gammella, E., Maccarinelli , F., Buratti, P., Recalcati, S. and Cairo, G. (2014), "The role of iron in anthracycline cardiotoxicity", Front. Pharmacol., No. 5, pp. 25. https://doi.org/10.3389/fphar.2014.00025
- Wenjing, Xu , Tomasa Barrientos , Lan Mao , Howard A Rockman, Anthony A Sauve and Nancy C Andrews (2015), "Lethal cardiomyopathy in mice lacking transferrin receptor in the heart", Cell Rep., No.13, pp. 533-545. https://doi.org/10.1016/j.celrep.2015.09.023
- Hasan Badie Bostan , Ramin Rezaee , Mahmoud Gorji Valokala , Konstantinos Tsarouhas, Kirill Golokhvast , Aristidis M Tsatsakis and Gholamreza Karimi (2016)," Cardiotoxicity of nanoparticles", Life Sciences, No. 16, pp. 91-99. https://doi.org/10.1016/j.lfs.2016.09.017
- Hadrup N. and Lam H.R. (2014), "Oral toxicity of silver ions, silver nanoparticles and colloidal silver - a review", Regul. Toxicol. Pharmacol.; No. 68(1), pp. 1-7. https://doi.org/10.1016/j.yrtph.2013.11.002
- Yong Soon Kim, Moon Yong Song, Jung Duck Park, et al.. (2010), "Subchronic oral toxicity of silver nanoparticles", Part. Fibre Toxicol., No. 7, pp. 20. https://doi.org/10.1186/1743-8977-7-20
- Korani M., Rezayat S.M., S.M. and Sepideh Arbabi Bidgoli. (2013) "Sub-chronic dermal toxicity of silver nanoparticles in guinea pig: special emphasis to heart, bone and kidney toxicities", Iran J. Pharm. Res, No. 12(3), pp. 511-519.
- Petrickaya E.N., Abaeva L.F., Rogatkin D.A., et al.. (2014), "Nekotorye proyavleniya kardiotoksichnosti nanochastic zolota", Nanotehnika, No. 3, pp. 42.
- Surekha Pasupuleti , Srinivas Alapati, Selvam Ganapathy, Goparaju Anumolu, Neelakanta Reddy Pully, Balakrishna Murthy Prakhya (2012), "Toxicity of zinc oxide nanoparticles through oral route", Toxicol. Ind. Health., No. 28(8), pp. 657-686. https://doi.org/10.1177/0748233711420473
- Vandebriel, R.J., WH. De Jong (2012), "A review of mammalian toxicity of ZnO nanoparticles", Nanotechnol. Scin. Appl., No. 5, pp. 61-71. https://doi.org/10.2147/NSA.S23932
- Hsiao-Chi Chuang, Hung-Tzu Juan, Chun-Nung Chang and Yuan-Horng Yan (2013), "Cardiopulmonary toxicity of pulmonary exposure to occupationally relevant zinc oxide nanoparticles", Nanotoxicology, No. 8(6), pp. 593-604. https://doi.org/10.3109/17435390.2013.809809
- Baky, N.A., Faddah, L.M., Al-Rasheed, N.M., Al-Rasheed, N.M. and Fatani, A .J. (2013), "Induction of inflammation, DNA damage and apoptosis in rat heart after oral exposure to zinc oxide nanoparticles and the cardioprotective role of alpha lipoic acid and vitamin E", Drug Research., No. 63(5), pp. 228-236. https://doi.org/10.1055/s-0033-1334923
- Jing Sun, Shaochuang Wang, Dong Zhao, Fei Han Hun, Lei Weng and Hui Liu (2011), "Cytotoxicity, permeability and inflammation of metal oxide nanoparticles "; Cell Biol. Toxicol., No. 27(5), pp. 333-342. https://doi.org/10.1007/s10565-011-9191-9
- Shiyuan Liu, Yu Han, Longping Yin, Ling Long and Rui Liu. (2008), "Toxicology studies of a superparamagnetic iron oxide nanoparticle in vivo" Adv. Mater. Res., No. 47-50, pp. 1097-1100. https://doi.org/10.1080/21691401.2019.1709855
- Mahmoudi, M., Hofmann, H., Rothen-Rutishauser, B. and Petri-Fink, A. (2010). "Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles", Chem. Rev., No. 112(4), pp. 2323-2338. https://doi.org/10.1021/cr2002596
- Seong Cheol Hong , Jong Ho Lee, Jaewook Lee, Hyeon Yong Kim et al. (2011), "Subtle cytitoxicity and genotoxicity differences in superparamagnetic iron nanoparticles coated with various functional groups", Int. Nanomedicine, No. 6, pp. 3219-3231. https://doi.org/10.2147/IJN.S26355
- Xinying Wu , Yanbin Tan, Hui Mao and Minming Zhang (2010), "Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells", International Journal of Nanomedicine, No. 5, pp. 385-399. https://doi.org/10.2147/IJN.S10458
- Andrea Gojova , Bing Guo, Rama S Kota, John C Rutledge, Ian M Kennedy and Abdul I Barakat (2007), "Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition", Environ Health Perspect., No. 115(3), pp. 403-409. https://doi.org/10.1289/ehp.8497