You are using an outdated browser. For a faster, safer browsing experience, upgrade for free today.

New approaches to hygienic regulation of optimal concentrations of toxic metals and essential trace elements in human biological media

ISSN 2223-6775 Ukrainian journal of occupational health Vol.18, No 2, 2022


https://doi.org/10.33573/ujoh2022.02.096

New approaches to hygienic regulation of optimal concentrations of toxic metals and essential trace elements in human biological media

Ischeikin K.E., Andrusyshyna I.M., Golub I.O., Lampeka O.G., Pivovar T.M., Tsapko V.G.
SI "Yu Kundiiev Institute for Occupational Health of the NAMS of Ukraine", Kyiv, Ukraine


Full article (PDF): ENG / UKR

Introduction. The article presents approaches to the methodology of normalization of optimal levels of toxic metals and essential trace elements in human biological environments. Currently, the concept of norm is not a constant value due to the heterogeneity of geochemical living conditions, bad habits, diet, age and differences. The application of various analytical methods for the determination of chemical elements has led to significant disagreements in determining the boundaries of their physiological norm in human biological environments.

The aim of the study. To give an ecological and hygienic assessment of the influence of toxic metals and essential microelements on the formation of optimal levels of their content in biological environments.

Materials and methods. The content of toxic metals and essential trace elements was determined in the environment (atmospheric air, drinking water, food) and biological environments of healthy volunteers (hair, whole blood, serum). An optical emission spectrometry with inductively coupled plasma (OES-ICP), questionnaire methods, and mathematical statistics were used to determine the content of toxic metals.

Conclusions. The results of research have shown a close relationship between the chemical composition of air, drinking water, food in the formation of optimal levels of macro-and micronutrients in human biological environments. The content of MaE and ME in the biological media studied in some cases corresponded to the minimum physiological levels (for Pb, Zn, Cd, Mg, Cr, Se), for Mn, Fe, Cu, Ni, Ca the optimal value was found, but for Al, As the content corresponded to the maximum physiological levels. Chemical elements, the concentration of which in biological media was in the range of "g - mg" (for Ca, Mg, K, Na, Fe, Cu, Zn in serum), were within the "conditional norm" when determined by the ECO-ISP method. To identify the risk of imbalance of macro- and micronutrients in the human body, it is necessary to use an integrated approach (simultaneous determination of metal content in several biological media) and apply multi-element analysis methods at both individual and population levels.

Keywords: toxic metals, trace elements, optimal levels of metal content, reference values, macro- and microelements, biological media.

References

  1. Oberlis, D., Harland, B., Skalny, A. (2008), The biological role of macro- and micronutrients in humans and animals, SPb, Nauka, 544 p.
  2. Shvyryaev, A.A., Menshikov, V.V. Risk assessment of air pollution in the study region: A textbook for universities, MSU Publishing House, Moscow, 2004. 124 p.
  3. Hygienic criteria of the state of the environment 155 Biomarkers and risk assessment. Concepts and Principles, 1996 WHO 96 p.
  4. Serdyuk, A.M., Turos, O.I., Kartavtsev, O.M. et all. (2005), Guidelines for assessing the risk to public health from air pollution from industrial emissions. Kiyv, 38 c.
  5. Andrusyshyna, I.M. Lampeka, O.G., Golub, I.O., Lubyanova, I.P. Kharchenko, T.D. (2007), Methodical recommendations (111) 72.14 / 133.14 "Evaluation of the destruction of mineral exchange in professional contingents by the method of atomic emission spectrometry with inductively coupled plasma". Avicena, 2014, 60 p.
  6. Determination of 33 elements by atomic emission spectrometry with inductively coupled plasma in water. ISO 11885:1996, Kyiv, Derzhspozhyvstandart Ukraine, 14 p.
  7. Metal and metalloid particulates in workplace atmospheres (ICP analysis), available at: File://E:/nioshdbs/oshameth/id125g/id25/id15g.htm
  8. Interstate standard. (2000), GOST 30538-97. Food products. Analysis of toxic elements by atomic-emission method, Adopted by the State Standard of Ukraine No. 12 from 11.21.97, 32 p.
  9. Antomonov, M.Y. (2006), Mathematical processing and analysis of medical and biological data, MDF, Kyiv, 558 p.
  10. Andrusyshyna, I.N., Lampeka, E.G., Golub, I.A. (2013), "Microelementosis in Ukraine (before the problem of measuring spectral methods for assessing ecologically and professionally summarizing the problems of mineral exchange among people", Science Journal of the Ministry of Health of Ukraine, Vol. 3, No. 4, pp. 136-146.
  11. Demchenko, V.F. Lubyanova, I.P. Andrusyshyna, I.M. et all. (2012), "Features of application of non-invasive biological substrates in biomonitoring of exposure to heavy metals in production", Ukrainian Journal of Occupational Health, No. 4, pp. 29-35. https://doi.org/10.33573/ujoh2012.04.029
  12. Paranko, N.M. Belitskaya, Karnaukh, N.G., Rublevskaya, N.I., Sita, S.G. (2002), Heavy metals of the environment and their effects on the immune status of the population, Printing, Dnepropetrovsk, 14. p.
  13. Tolmacheva, N. V., Suslikov, V. L., Vinokur, T. Yu. (2011), "Ecological and physiological substantiation of the norms of optimal levels and the ratio of macro- and microelements in drinking water and daily food rations", Medical Sciences, No. 3, pp. 155-160.
  14. Rakhmanin, Yu. A., Shashina, T. A., Novikov, S. M. (2007), "Modern trends in risk assessment methodology", Hygiene and sanitation, No. 3, pp. 3-8.
  15. Trachtenberg, I.M. (2005), Essay 6 - Age differences in the content of some chemical elements in humans and experimental animals. Essays on age toxicology, for ed. IM Trachtenberg, VD Avicenna, Kyiv, 256 p.
  16. Jaishankar, M., Tseten, T., Anbalagan, N. et all. (2014), "Toxicity, mechanism and health effects of some heavy metals", Interdiscip Toxicol, Vol. 7, No. 2, 60-72, https://doi.org/10.2478/intox-2014-0009
  17. Rosborg, I., Kozisek, F., Selinus, O. et al. (2015), Drinking water minerals and mineral balance, SIP, Switzerland, 105 p. https://doi.org/10.1007/978-3-319-09593-6
  18. Stojsavljević, A., Jagodić, J., Vujotić, L. et al. (2020), "Reference values for trace essential elements in the whole blood and serum samples of the adult Serbian population: significance of selenium deficiency", Environ Sci Pollut Res Int, Vol. 27, No. 2, pp.1397-1405, https://doi.org/10.1007/s11356-019-06936-8
  19. Saravanabhavan, G., Werry, K., Walker, M. et al. (2016), "Human biomonitoring reference values for metals and trace elements in blood and urine derived from the Canadian health measures survey 2007-2013", Inter. J. of Hygiene and Environmental health, 12 p., available at: journal home page: www.elservier.com/locate/ijheh. https://doi.org/10.1016/j.ijheh.2016.10.006
  20. Fowler, P. A., Bellingham, M. Sinclair, K. D. et al. (2012), "Impact of endocrine-disrupting compounds (EDCs) on female reproductive health", Mol. Cell. Endocrinol, Vol. 355, pp. 231-239, https://doi.org/10.1016/j.mce.2011.10.021
  21. Michalke, D. (2017), "Speciation in trace elements analysis:combination with metabolism and application to neurodegenerative disorders", J. of Trace Elem, Vol. 41 (S1), pp. 8.