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New approaches to hygienic regulation of optimal concentrations of toxic metals and essential trace elements in human biological media

ISSN 2223-6775 Ukrainian journal of occupational health Vol.18, No 2, 2022

New approaches to hygienic regulation of optimal concentrations of toxic metals and essential trace elements in human biological media

Ischeikin K.E., Andrusyshyna I.M., Golub I.O., Lampeka O.G., Pivovar T.M., Tsapko V.G.
SI "Yu Kundiiev Institute for Occupational Health of the NAMS of Ukraine", Kyiv, Ukraine

Full article (PDF): ENG / UKR

Introduction. The article presents approaches to the methodology of normalization of optimal levels of toxic metals and essential trace elements in human biological environments. Currently, the concept of norm is not a constant value due to the heterogeneity of geochemical living conditions, bad habits, diet, age and differences. The application of various analytical methods for the determination of chemical elements has led to significant disagreements in determining the boundaries of their physiological norm in human biological environments.

The aim of the study. To give an ecological and hygienic assessment of the influence of toxic metals and essential microelements on the formation of optimal levels of their content in biological environments.

Materials and methods. The content of toxic metals and essential trace elements was determined in the environment (atmospheric air, drinking water, food) and biological environments of healthy volunteers (hair, whole blood, serum). An optical emission spectrometry with inductively coupled plasma (OES-ICP), questionnaire methods, and mathematical statistics were used to determine the content of toxic metals.

Conclusions. The results of research have shown a close relationship between the chemical composition of air, drinking water, food in the formation of optimal levels of macro-and micronutrients in human biological environments. The content of MaE and ME in the biological media studied in some cases corresponded to the minimum physiological levels (for Pb, Zn, Cd, Mg, Cr, Se), for Mn, Fe, Cu, Ni, Ca the optimal value was found, but for Al, As the content corresponded to the maximum physiological levels. Chemical elements, the concentration of which in biological media was in the range of "g - mg" (for Ca, Mg, K, Na, Fe, Cu, Zn in serum), were within the "conditional norm" when determined by the ECO-ISP method. To identify the risk of imbalance of macro- and micronutrients in the human body, it is necessary to use an integrated approach (simultaneous determination of metal content in several biological media) and apply multi-element analysis methods at both individual and population levels.

Keywords: toxic metals, trace elements, optimal levels of metal content, reference values, macro- and microelements, biological media.


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