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Predicting the risk of combined exposure of workers to Trident and VG herbicide

ISSN 2223-6775 Ukrainian journal of occupational health Vol.19, No 2, 2023

Predicting the risk of combined exposure of workers to Trident and VG herbicide

Kovalenko V.F., Dontsova D.O., Prygunova V.V.
State Institution "Kundiev Institute of Occupational Medicine of the National Academy of Medical Sciences of Ukraine", Kyiv

Full article (PDF): ENG / UKR

Introduction. Since broad-spectrum herbicides are mostly ineffective for the destruction of cereal weeds, it is recommended to use tank mixtures of herbicides or combined preparations. The problem of weed resistance to herbicides is also worthy of attention. To date, 113 weed species have been registered as resistant, including almost 60 species to triazine derivatives [1]. Every year, the agricultural market increases the supply of complex mixtures of pesticide formulations containing two or more active ingredients, which increases the likelihood of their dangerous effects on workers.

Purpose of the study. The aim of the study is to predict the risk of occupational combined exposure to tribenuron-methyl, florasulam and flumetsulam when using their mixture to protect crops of spiked cereals.

Materials and methods of the research. Trident, VG combined herbicide, experimental studies on laboratory animals to study acute oral toxicity using the OECD method No. 423, field studies of occupational conditions when using the herbicide in the treatment of cereals; exposure doses of tribenuron-methyl, florasulam and flumetsulam, risk assessment of complex (inhalation and dermal) exposure of workers to active substances using a predictive risk assessment model; methods of expert-analytical study of scientific information on toxicological properties

Results. On the example of a mixed pesticide composition based on tribenuron-methyl (chemical class of compounds - sulfonylurea), florasulam and flumetsulam (chemical class of compounds - triazole pyrimidine derivatives), it was found that the combined effect of these substances is characterized by a potentiation effect. The potentiation coefficient for a specific mixture composition of these substances is 4.76. The combined risk of exposure to Trident, VG herbicide is permissible E=0.296.

Conclusions. The increasing frequency of the use of multicomponent pesticide formulations poses a threat of possible potentiation as one of the most dangerous types of combined effects. The necessity of taking into account the potentiation coefficients when studying occupational conditions with the use of combined preparations based on active substances with a similar type of toxic effects is substantiated. This will increase the accuracy and reliability of the results of occupational risk assessment and will contribute to the development of preventive measures to prevent the harmful effects of pesticides on workers.

Keywords: mixed insecticide, tribenuron-methyl, florasulam, flumetsulam, toxicological and hygienic assessment, combined risk prediction.


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