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Prediction of the occurrence of acute toxic effects during skin and inhalation influence of fungicides different classes on agricultural workers

ISSN 2223-6775 Ukrainian journal of occupational health Vol.19, No 2, 2023


https://doi.org/10.33573/ujoh2023.02.098

Prediction of the occurrence of acute toxic effects during skin and inhalation influence of fungicides different classes on agricultural workers

Bardov H.P.
Hygiene and ecology department # 1, O.O. Bogomolets National Medical University, Kyiv, Ukraine


Full article (PDF): ENG / UKR

Introduction The problem of the occupational safety stays relevant. A special issue is given to the effect of dermal chemical protection agents through direct contact. The most common occupational skin diseases associated with the using of pesticides are onycholysis, contact dermatitis, and nail deformation.

The aim of the research is prediction of the occurrence of acute toxic effects during dermal and inhalation exposure of fungicides different classes on agricultural workers.

Materials and methods of the research. Prediction of acute toxic effects was done by using the coefficient of possible inhalation poisoning (CPIP), the coefficient of selective action of the pesticide after inhalation and dermal exposure (CSAing., CSAd.). Statistical analysis of the obtained results was carried out using the MS Excel program (2000) and the license package IBM SPSS Statistics Base v.22.

Results It has been established that for CPIP all analyzed fungicides of different classes are of low danger (IV class of danger) according to DSanPiN 8.8.1.002-98. The ranking of fungicides according to this criterion shows that the most dangerous are fungicides of anilinopyrimidines class > amides > phenylpyrroles and thiazoles > benzamides and triazoles.

A comparative analysis of CSA values for different ways of exposure of the studied active substances showed that it is significantly higher with dermal exposure for almost all analyzed classes of fungicides (р≤0.05), with the exception of mandipropamide, for which the differences were insignificant (р>0.05).

Significantly higher CSA values were obtained in inhalation exposure, compared to CSA values in dermal exposure of the analyzed pesticide formulations (р≤0.05). The obtained results showed that almost all formulations of fungicides are significantly more dangerous during inhalation way of exposure.

Conclusions. Our findings indicate a significantly higher risk for professional groups when using the analyzed fungicides with inhalation exposure, which should be taken into account when planning work with this group of chemical plant protection products.

Keywords: pesticides, risk, prediction occupational skin diseases, poisoning, chemical pollution of working zone.

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