The method of read-across as a basis for group standardization of harmful compounds in the air of the working area (as exemplified by dialkyldimethylammonium chlorides C8-C10 homologues)
Turkina V.A., Alyokhina T.A.
Danylo Halytsky Lviv National Medical University, Lviv
Full article (PDF): ENG / UKR
Introduction. The situation of recent years during the SARS-CoV-2 pandemic has aggravated the problem of an insufficient number of approved hygienic standards of active substances included in disinfectants. This, in turn, has become a deterrent to the introduction of such agents into practice. For the proper organization of chemical safety of the workforce new methods of substantiating hygienic standards need to be developed. One of the ways to overcome the outlined higher problem, which will significantly speed up the resolution of the situation, is the introduction of read-across as an express method of substantiating the maximum permissible concentrations for a group (cluster) of compounds.
The purpose of the research is to substantiate the possibilities of developing group regulations for this cluster of compounds in the air of the working area based on data about the physicochemical and toxicological characteristics of dialkyldimethylammonium chloride С8-С10 homologues.
Results. Similar chemical structure of dialkyldimethylammonium chloride C8-C10 homologues determines their similarity in terms of physicochemical and toxicological properties. All substances are solids in their aggregate state, dissolve well in water, have the ability to penetrate biological membranes and disrupt their integrity. According to parameters of acute oral toxicity, dialkyldimethylammonium chloride C8-C10 homologues belong to moderately hazardous substances – hazard class 3, do not cause systemic toxicity; the main negative manifestation of their influence is an irritating effect which further provokes signs of general toxicity. The substances do not have carcinogenic, mutagenic effects, they do not affect reproductive function. The most studied representative of the cluster is didecyldimethylammonium chloride (DC10DAC), which is accepted as a standard (analogue) for all dialkyldimethylammonium chloride C8-C10 homologues. In Ukraine a temporary hygienic standard for didecyldimethylammonium chloride in the air of the working area (approximately safe exposure level, ASEL) has been approved at the level of 0.2 mg/m3, where the limiting criteria for harmfulness are pronounced irritating effect on the skin and mucous membranes of the eyes and an acute inhalation effect. The calculation standard for quaternary ammonium compounds proposed by Dotson G.S. et al. is 0.1 mg/m3. Both standards belong to the II class of safety.
Conclusions. The read-across method allows for accepting didecyldimethylammonium chloride (DC10DAC) as a standard (analogue) for all dialkyldimethylammonium chloride C8-C10 homologues. The hygienic regulation of the permissible content of didecyldimethylammonium chloride obtained on the basis of additional experimental studies as a result of the application of the cluster approach will be legitimate for dioctyldimethylammonium chloride (DC8DAC); octyldecyldimethylammonium chloride (DC8-10DAC), didecyldimethylammonium chloride (DC10DAC) and their mixtures with different percentage ratios.
Keywords: dialkyldimethylammonium chloride C8-C10 homologues, dialkyl(C8-C10)dimethylammonium chloride, dioctyldimethylammonium chloride, didecyldimethylammonium chloride, read-across, hygienic standard, cluster approach, group hygienic regulation.
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