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Use of biomonitoring methodology for evaluation of metal exposure of population and workers

ISSN 2223-6775 Ukrainian journal of occupational health Vol.17, No 2, 2021

Use of biomonitoring methodology for evaluation of metal exposure of population and workers

Andrusyshyna I.M., Golub I.O., Lampeka O.G.

SI «Yu Kundiiev Institute for Occupational Health of the NAMS of Ukraine»1, Kyiv, Ukraine

Full article (PDF), UKR

Introduction. The article reflects modern ideas about the methodology for assessing the risk of endocrine pathology under the conditions of exposure to Al, Ag, Cr, Mn. Highlighted approaches allowed to justify metal concentrations in biological environments of adults and workers that meet the acceptable level of health risk by functional change endocrine system.

The aim of the study. Analysis of the current state of regulatory and methodological framework human biomonitoring approaches to assessment procedures metals research results in biological environments of individuals with different functional status (age, healthy individuals and professional groups).

Materials and methods. The study used biological media - whole blood and hair of volunteers, people with established pathology and workers. The subjects consisted of 3 groups: the first - people who had no signs of abnormal health, the second included people with pathology of the endocrine system and the third - people who had professional contact with metals in the workplace (electric welders). The content of 4 chemical elements (Al, Ag, Mn, Cr) was determined in the biological media of the subjects (whole blood, blood serum and hair) using the method of multielement analysis - optical emission spectrometry with inductively coupled plasma (OES-IZP). Statistical processing of the obtained results was performed and ROC curves were constructed, which indicate the risk of endocrine pathology development depending on the level of metal content in the biological environment.

Conclusions. The conducted research provided an opportunity to expand the methodological approaches to assessing the risk of endocrine pathology. It is shown that the risk of nonspecific effects of the endocrine system is high under the influence of Aluminum and Manganese. This contributed to justifscftion the optimal levels of their content in human biological environments and to assess the ecologically determined risk of endocrine disorders in humans.

Key words: heavy metals, essential microelements, biological media, permissible levels, risk of endocrine diseases.


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